American Journal of Obstetrics & Gynecology
Volume 198, Issue 4 , Pages 389.e1-389.e5 , April 2008

Maternal periodontal disease, systemic inflammation, and risk for preeclampsia

Presented at the 53rd Annual Scientific Meeting of the Society for Gynecologic Investigation, Toronto, ON, Canada, March 22-25, 2006.

  • Michael Ruma, MD

      Affiliations

    • Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC
    • Corresponding Author InformationReprints: Michael S. Ruma, MD, 214 MacNider Bldg, CB #7516, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7516.
    • ,
  • Kim Boggess, MD

      Affiliations

    • Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC
    • ,
  • Kevin Moss

      Affiliations

    • Department of Dental Ecology, University of North Carolina at Chapel Hill School of Dentistry, Chapel Hill, NC
    • ,
  • Heather Jared, MS

      Affiliations

    • Department of Dental Ecology, University of North Carolina at Chapel Hill School of Dentistry, Chapel Hill, NC
    • ,
  • Amy Murtha, MD

      Affiliations

    • Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC.
    • ,
  • James Beck, PhD

      Affiliations

    • Department of Dental Ecology, University of North Carolina at Chapel Hill School of Dentistry, Chapel Hill, NC
    • ,
  • Steven Offenbacher, DDS, PhD

      Affiliations

    • Department of Periodontology, University of North Carolina at Chapel Hill School of Dentistry, Chapel Hill, NC

Received 19 January 2007 ,Revised 3 December 2007 ,Accepted 6 December 2007.

References 

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  2. Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000. 2001;25:8–20
  3. Kornman KS, Page RC, Tonetti MS. The host response to the microbial challenge in periodontitis: assembling the players. Periodontol 2000. 1997;14:33–53
  4. Beck JD, Pankow J, Tyroler HA, Offenbacher S. Dental infections and atherosclerosis. Am Heart J. 1999;138:528–533
  5. Cueto A, Mesa F, Bravo M, Ocana-Riola R. Periodontitis as risk factor for acute myocardial infarction (A case control study of Spanish adults). J Periodontal Res. 2005;40:36–42
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  7. Boggess KA, Lieff S, Murtha AP, Moss K, Beck J, Offenbacher S. Maternal periodontal disease is associated with an increased risk for preeclampsia. Obstet Gynecol. 2003;101:227–231
  8. Canakci V, Canakci CF, Canakci H, et al. Periodontal disease as a risk factor for pre-eclampsia: a case control study. Aust N Z J Obstet Gynaecol. 2004;44:568–573
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  13. Takacs P, Green KL, Nikaeo A, Kauma SW. Increased vascular endothelial cell production of interleukin-6 in severe preeclampsia. Am J Obstet Gynecol. 2003;188:740–744
  14. Belo L, Santos-Silva A, Rocha S, et al. Fluctuations in C-reactive protein concentration and neutrophil activation during normal human pregnancy. Eur J Obstet Gynecol Reprod Biol. 2005;123:46–51
  15. Belo L, Santos-Silva A, Caslake M, et al. Neutrophil activation and C-reactive protein concentration in preeclampsia. Hypertens Pregnancy. 2003;22:129–141
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  17. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105:1135–1143
  18. Rifai N, Tracy RP, Ridker PM. Clinical efficacy of an automated high-sensitivity C-reactive protein assay. Clin Chem. 1999;45:2136–2141
  19. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836–843
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  24. North Carolina State Center for Health Statistics. North Carolina: Department of Health and Human Services. [updated 2006 March 6; cited 2006 Jul 24] http://www.schs.state.nc.us/SCHS/prams/

 Cite this article as: Ruma M, Boggess K, Moss K, et al. Maternal periodontal disease, systemic inflammation, and risk for preeclampsia. Am J Obstet Gynecol 2008;198:389.e1-389.e5.

 Supported by NIDCR grant R01-DE012453, NCRR RR00046, and NICHD K08HD043284, RO1HD26652, and K12HD01441.

PII: S0002-9378(07)02266-1

doi: 10.1016/j.ajog.2007.12.002

American Journal of Obstetrics & Gynecology
Volume 198, Issue 4 , Pages 389.e1-389.e5 , April 2008

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