American Journal of Obstetrics & Gynecology
Volume 199, Issue 1 , Pages 67.e1-67.e5, July 2008

Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol

  • Iga N. Wegorzewska, BS

      Affiliations

    • Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD
    • ,
  • Katy Walters, BS

      Affiliations

    • Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD
    • ,
  • Michael J. Weiser, MS

      Affiliations

    • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO.
    • ,
  • Danette F. Cruthirds, CRNA, MSN, AN, US Army

      Affiliations

    • Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD
    • ,
  • Emily Ewell, BS

      Affiliations

    • Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD
    • ,
  • Darwin O. Larco, BS

      Affiliations

    • Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD
    • ,
  • Robert J. Handa, PhD

      Affiliations

    • Department of Biomedical Sciences, Colorado State University, Fort Collins, CO.
    • Corresponding Author InformationReprints: T. John Wu, PhD, Department of Obstetrics and Gynecology, Room B2020, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, or Robert J. Handa, PhD, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523.
    • ,
  • T. John Wu, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, MD
    • Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, MD
    • Corresponding Author InformationReprints: T. John Wu, PhD, Department of Obstetrics and Gynecology, Room B2020, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, or Robert J. Handa, PhD, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523.

Received 23 May 2007; received in revised form 6 September 2007; accepted 26 November 2007. published online 13 February 2008.

Objective

The objective of this study was to distinguish the role of specific estrogen receptors (ERs), ERα and ERβ, on body weight regulation using a rat model of weight gain subsequent to menopause.

Study Design

Ovariectomized rats were utilized as the animal model to simulate the postmenopause weight gain. The rats were ovariectomized and subcutaneously injected daily with vehicle, estradiol-17β (E2), propylpyrazoletriol (PPT; ERα agonist) and diarylpropionitrile (DPN; ERβ agonist). To further control for the possible effect of estrogen secreted from adrenals, a second experiment was conducted during which the rats were adrenalectomized and ovariectomized.

Results

Ovariectomy significantly increased (P < .05) body weight, whereas treatment of ovariectomized rats with E2 and PPT, but DPN decreased (P < .05) body weight. The results from the second study with ovariectomized/adrenalectomized rats were consistent with the first experiment.

Conclusion

These results suggest that the activation of ERα is important in regulating body weight.

Key words: adrenalectomy, body weight, menopause, ovariectomy, rat, specific estrogen receptor modulators

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 This study was supported by US Department of Defense Grant H085BL (to T.J.W.); US Department of Defense Grant USAMRMC-04182001 (to T.J.W. and R.J.H.); and National Institutes of Health Grant NS039951 (to R.J.H.).The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the US Department of Defense or of the Uniformed Services University of the Health Sciences.Cite this article as: Wegorzewska IN, Walters K, Weiser MJ, et al. Postovariectomy weight gain in female rats is reversed by estrogen receptor α agonist, propylpyrazoletriol. Am J Obstet Gynecol 2008;199:67.e1-67.e5.

PII: S0002-9378(07)02238-7

doi:10.1016/j.ajog.2007.11.054

American Journal of Obstetrics & Gynecology
Volume 199, Issue 1 , Pages 67.e1-67.e5, July 2008

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