American Journal of Obstetrics & Gynecology
Volume 198, Issue 4 , Pages 440-450 , April 2008

Group B Streptococcus and pregnancy: a review

  • John W. Larsen, MD

      Affiliations

    • The George Washington University, Washington, DC
    • Corresponding Author InformationReprints: John W. Larsen, MD, 2150 Pennsylvania Ave, NW, Floor 6A, Washington, DC 20037.
    • ,
  • John L. Sever, MD, PhD

      Affiliations

    • The George Washington University, Washington, DC
    • Children’s National Medical Center, Washington, DC.

Received 18 April 2007 ,Accepted 15 November 2007.

References 

  1. Hare R, Colebrook L. The biochemical reactions of hemolytic streptococci from the vagina of febrile and afebrile parturient women. J Pathol Bacteriol. 1934;39:429–442
  2. Lancefield RC, Hare R. The serological differentiation of pathogenic and non-pathogenic strains of hemolytic streptococci from parturient women. J Exp Med. 1935;61:335–349
  3. Fry RM. Fatal infections by hemolytic Streptococcus group B. Lancet. 1938;1:199–201
  4. Hood M, Janney A, Dameron G. Beta hemolytic Streptococcus group B associated with problems of the perinatal period. Am J Obstet Gynecol. 1961;82:809–818
  5. Burman LG, Christensen P, Christensen K, et al. Prevention of excess neonatal morbidity associated with group B Streptococci by vaginal chlorhexidine study group. Lancet. 1992;340:65–69
  6. Regan JA, Klebanoff MA, Nugent RP, et al. Colonization with group B Streptococci in pregnancy and adverse outcome: VIP study group. Am J Obstet Gynecol. 1996;174:1354–1360
  7. Daley AJ, Garland SM. Prevention of neonatal group B streptococcal disease: progress, challenges and dilemmas. J Pediatr Child Health. 2004;40:664–668
  8. Royal College of Obstetricians and Gynecologists. Prevention of early onset neonatal group B streptococcal disease. RCOG Guideline. 2003;36:1
  9. Avery M, Brown HW, Schrag S. Disparities in universal prenatal screening for group B Streptococcus–North Carolina, 2002-2003. MMWR Morb Mortal Week Rep. 2005;54:700–703
  10. Réglier-Poupet H, Quesne G, Le Théo E, et al. Prospective evaluation of a real-time PCR assay for detection of group B Streptococci in vaginal swabs from pregnant women. Eur J Clin Microbiol Infect Dis. 2005;24:355–357
  11. Kenyon S, Brocklehurst P, Blackburn A, Taylor DJ. Antenatal screening and intrapartum management of group B Streptococcus in the UK. BJOG. 2004;111:226–230
  12. Campbell N, Eddy A, Darlow B, Stone P, Grimwood K. The prevention of early: onset neonatal group B Streptococcus infection: technical report from the New Zealand GBS Consensus Working Party. N Z Med J. 2004;117:1–19
  13. Yũcesoy G, Çalişkan E, Karadenizli A, et al. Maternal colonization with group B Streptococcus and effectiveness of a culture-based protocol to prevent early-onset neonatal sepsis. Int J Clin Pract. 2004;58:735–739
  14. Weisner AM, Johnson AP, Lamagni TL, et al. Characterization of group B Streptococci recovered from infants with invasive disease in England and Wales. Clin Infect Dis. 2004;38:1203–1208
  15. Wilkinson HW, Facklam RR, Wortham EC. Distribution by serological type of group B Streptococci isolated from a variety of clinical material over a five-year period (with special reference to neonatal sepsis and meningitis). Infect Immun. 1973;8:228–235
  16. Franciosi RA, Knostman JD, Zimmerman RA. Group B streptococcal neonatal and infant infections. J Pediatr. 1973;82:707–718
  17. Yow MD, Mason EO, Leeds LJ, Thompson PK, Clark DJ, Gardner SE. Ampicillin prevents intrapartum transmission of group B Streptococcus. JAMA. 1979;241:1245–1247
  18. Lancefield RC, McCarty M, Everly WN. Multiple mouse-protective antibodies directed against group B Streptococci: special reference to antibodies effective against protein antigens. J Exp Med. 1975;142:165–179
  19. Deveikis A, Schauf V, Mizen M, Riff L. Antimicrobial therapy of experimental group B Streptococcus infection in mice. Antimicrob Agents Chemother. 1977;11:817–820
  20. Larsen JW, London WT, Palmer AE, et al. Experimental group B streptococcal infection in the rhesus monkey I: disease production in the newborn. Am J Obstet Gynecol. 1978;132:686–690
  21. Larsen JW, London WT, Palmer AE, Curfman BL, Bronsteen RA. Penicillin treatment for group B streptococcal meningitis in the rhesus monkey. Obstet Gynecol. 1981;57:330–334
  22. Larsen JW, London WT, Baker CJ, Curfman BL, Sever JL. Intraamniotic infection due to group B Streptococcus: treatment and antibody response. Obstet Gynecol. 1981;58:22–26
  23. Larsen JW, Harper JS, London WT, et al. Antibody to type III group B Streptococcus in the rhesus monkey. Am J Obstet Gynecol. 1983;146:958–962
  24. Bethea CL, Gravett MG, Sadowsky DW, Haluska GJ, Axethelm MK, Novy MJ. Amniotic fluid prolactin is decreased by experimental intrauterine infection or interleukin-1β infusion but not via prostaglandins in pregnant rhesus macaques. Biol Reprod. 1998;58:1385–1393
  25. Davies JK, Paoletti LC, McDuffie RS, et al. A randomized trial of conjugated group B streptococcal type Ia vaccine in a rabbit model of ascending infection. Am J Obstet Gynecol. 1999;181:803–808
  26. Baker CJ, Clark DJ, Barrett FF. Selective broth medium for isolation of group B Streptococci. Appl Microbiol. 1973;26:884–885
  27. Baker CJ, Goroff DK, Alpert SL, Hayes C, McCormack WM. Comparison of bacteriological methods for isolation of the group B Streptococcus from vaginal cultures. J Clin Microbiol. 1976;4:46–48
  28. Heelan JS, Struminsky J, Lauro P, Sung CJ. Evaluation of a new selective enrichment broth for detection of group B Streptococci in pregnant women. J Clin Microbiol. 2005;43:896–899
  29. Morales WJ, Lim D. Reduction of group B streptococcal maternal and neonatal infections in preterm pregnancies with premature rupture of membranes through a rapid identification test. Am J Obstet Gynecol. 1987;157:13–16
  30. Grossman JH, Kaye MF, Isada NB, Larsen JW. Rapid test plus ampicillin protocol for reduction of preterm group B streptococcal perinatal morbidity. J Matern Fetal Med. 1995;4:1–4
  31. Baker CJ. Inadequacy of rapid immunoassays for intrapartum detection of group B streptococcal carriers. Obstet Gynecol. 1996;88:51–55
  32. Prevention of perinatal group B streptococcal disease: revised guideline from CDC. MMWR Recomm Rep. 2002;51(RR-11):1–22
  33. Prevention of perinatal group B streptococcal disease: a public health perspective. MMWR Recomm Rep. 1996;45(RR-7):1–24
  34. Boyer KM, Gotoff SP. Prevention of early-onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis. N Engl J Med. 1986;314:1665–1669
  35. Committee on Technical BulletinsAmerican College of Obstetricians and Gynecologists. Group B streptococcal infections in pregnancy. In: Washington (DC): The College; 1992;p. 1–5Tech Bull No. 170
  36. Committee on Infectious Diseases and Committee on Fetus and Newborn. Guidelines for prevention of group B streptococcal (GBS) infection by chemoprophylaxis. Pediatrics. 1992;90:775–778
  37. Boyer KM, Gadzala CA, Kelly PD, Burd LI, Gotoff SP. Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease: II, predictive values of prenatal cultures. J Infect Dis. 1983;48:802–809
  38. Badri MS, Zawaneh S, Cruz AC, et al. Rectal colonization with group B Streptococcus: relation to vaginal colonization of pregnant women. J Infect Dis. 1977;135:308–312
  39. American College of Obstetricians and Gynecologists. Prevention of early-onset group B streptococcal disease in newborns. In: Washington (DC): The College; 2002;p. 1405–1412ACOG Committee Opinion No. 279
  40. Kircher SM, Meyer MP, Jordan JA. Comparison of a modified DNA hybridization assay with standard culture enrichment for detecting group B Streptococci in obstetric patients. J Clin Microbiol. 1996;34:342–344
  41. Larsen JW, Dooley SL. Group B streptococcal infections: an obstetrical viewpoint. Pediatrics. 1993;91:148–149
  42. Bergeron MG, Ke D, Ménard C, et al. Rapid detection of group B Streptococci in pregnant women at delivery. N Engl J Med. 2000;343:175–179
  43. Ke D, Ménard C, Picard FJ, et al. Development of conventional and real-time PCR assays for the rapid detection of group B Streptococci. Clin Chem. 2000;46:324–331
  44. Davies D, Miller MA, Faro S, Gregson D, Kehl SC, Jordan JA. Multicenter study of a rapid molecular-based assay for the diagnosis of group B Streptococcus colonization in pregnant women. CID. 2004;39:1129–1135
  45. Schrag SJ. The past and future of perinatal group B streptococcal disease prevention. Clin Infect Dis. 2004;39:1136–1138
  46. Straka M, Dela Cruz W, Blackmon C, et al. Rapid detection of group B Streptococcus and Escherichia coli in amniotic fluid using real-time fluorescent PCR. Infect Dis Obstet Gynecol. 2004;12:109–113
  47. Bergeron MG, Ke D. New DNA-based PCR approaches for rapid real-time detection and prevention of group B streptococcal infections in newborns and pregnant women. Expert Med Mol Rev. 2001;3:1–14
  48. Rallu F, Barriga P, Scrivo C, Martel-Laferriére V, Laferriére C. Sensitivities of antigen detection and PCR assays greatly increased compared to that of the standard culture method for screening for group B Streptococcus carriage in pregnant women. J Clin Microbiol. 2006;44:725–728
  49. Atkins KL, Atkinson RM, Shanks A, Parvin CA, Dunne WM, Gross G. Evaluation of polymerase chain reaction for group B Streptococcus detection using an improved culture method. Obstet Gynecol. 2006;108:488–491
  50. Natarajan G, Johnson YR, Zhang F, Chen KM, Worsham MJ. Real-time polymerase chain reaction for the rapid detection of group B streptococcal colonization in neonates. Pediatrics. 2006;118:14–22
  51. Peytavi R, Raymond FR, Gagné D, et al. Microfluidic device for rapid (<15 min) automated microarray hybridization. Clin Chem. 2005;51:1836–1844
  52. Patel DA, Pearlman MD. Point-of-care diagnosis of STIs in women. Contemp Obstet Gynecol. 2006;51:68–74
  53. Haberland CA, Benitz WE, Sanders GD, et al. Perinatal screening for group B Streptococci: cost-benefit analysis of rapid polymerase chain reaction. Pediatrics. 2002;110:471–480
  54. Lewin EB, Amstey MS. Natural history of group B Streptococcus colonization and its therapy during pregnancy. Am J Obstet Gynecol. 1981;139:512–515
  55. Merenstein GB, Todd WA, Brown G, Yost CC, Luzier T. Group B beta-hemolytic Streptococcus: randomized controlled treatment at term. Obstet Gynecol. 1980;55:315–318
  56. Committee on Obstetric PracticeAmerican College of Obstetricians and Gynecologists. Prevention of early-onset group B streptococcal disease in newborns. Washington (DC): The College; 1996;ACOG Committee Opinion No. 173
  57. Bartholomew ML, Ashkin E, Schiffman A, Larsen JW. Maternal temperature variation during parturition. Obstet Gynecol. 2002;100:642–647
  58. Rosenstein NE, Schuchat AE. Opportunities for prevention of perinatal group B streptococcal disease: a multi-state surveillance analysis. Obstet Gynecol. 1997;90:901–906
  59. Schrag SJ, Zell ER, Lynfield R, et al. A population-based comparison of strategies to prevent early-onset group B streptococcal disease in neonates. N Engl J Med. 2002;347:233–239
  60. Stoner KA, Rabe LK, Hillier SL. Effect of transport time, temperature, and concentration on the survival of group B Streptococci in amies transport medium. J Clin Microbiol. 2004;42:5385–5387
  61. Simoes JA, Aroutcheva AA, Heimler I, Faro S. Antibiotic resistance patterns of group B streptococcal clinical isolates. Infect Dis Obstet Gynecol. 2004;12:1–8
  62. Manning SD, Foxman B, Pierson DL, Tallman P, Baker CJ, Perlman MD. Correlates of antibiotic-resistant group B Streptococcus isolated from pregnant women. Am J Obstet Gynecol. 2003;101:74–79
  63. Baker CJ, Kasper DL. Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection. N Engl J Med. 1976;294:753–756
  64. Baker CJ, Kasper DL, Tager IRAB, et al. Quantitative determination of antibody to capsular polysaccharide in infection with type III strains of group B Streptococcus. J Clin Invest. 1977;59:810–818
  65. Baker CJ, Kasper DL. Immunological investigation of infants with septicemia or meningitis due to group B Streptococcus. J Infect Dis. 1977;136(suppl):S98–S104
  66. Baker CJ, Edwards MS, Kasper DL. Immunogenicity of polysaccharides from type III group B Streptococcus. J Clin Invest. 1978;61:1107–1110
  67. Baker CJ, Edwards MS. Group B streptococcal conjugate vaccines. Arch Dis Childhood. 2003;88:375–378
  68. Baker CJ, Rench MA, McInnes P. Immunization of pregnant women with group B streptococcal type III capsular polysaccharide-tetanus toxoid conjugate vaccine. Vaccine. 2003;21:3468–3472
  69. Kasper DL, Paoletti LC, Wessels MR, et al. Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine. J Clin Invest. 1996;98:2308–2314
  70. Maione D, Margarit I, Rinaudo CD, et al. Identification of a universal group B Streptococcus vaccine by multiple genome screen. Science. 2005;309:148–150
  71. Rosini R, Rinaudo CD, Soriani M, et al. Identification of novel genomic islands coding for antigenic pilus-like structures in Streptococcus agalactiae. Mol Microbiol. 2006;61:126–141
  72. Buccato S, Maioine D, Rinaudo CD, et al. Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease. J Infect Dis. 2006;194:331–340
  73. Sinha A, Lieu TA, Paoletti LC, Weinstein MC, Platt R. The projected health benefits of maternal group B streptococcal vaccination in the era of chemoprophylaxis. Vaccine. 2005;23:3187–3195
  74. Edwards MS, Nizet V, Baker CJ. Ch 13 group B streptococcal infections. In: Remington , Klein , Wilson , Baker  editor. Infectious diseases of the fetus and newborn infant. 6th ed.. Philadelphia: Elsevier Saunders; 2006;p. 403–464
  75. Gibbs RS, Schrag S, Schuchat A. Perinatal infections due to group B Streptococci. Obstet Gynecol. 2004;104:1062–1076

PII: S0002-9378(07)02178-3

doi: 10.1016/j.ajog.2007.11.030

American Journal of Obstetrics & Gynecology
Volume 198, Issue 4 , Pages 440-450 , April 2008

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