Clinical effects of the levonorgestrel-releasing intrauterine device in patients with adenomyosis

Trial profile

The total number of women at admission was 47. There were 2 spontaneous expulsions of the LNG-IUD (at months 2 and 13) and 1 premature removal because of abdominal pain (at 1 month). At the end of study, there were 32 women: 10 patients participated less than 36 months but were still continuing follow-up evaluations, and 2 patients had the LNG-IUD replacement at 30 and 32 months because of increasing dysmenorrhea and vaginal bleeding. After the end of study, 15 patients had the original device removed and a new LNG-IUD was inserted.

Cho. Levonorgestrel-releasing intrauterine device and adenomyosis. Am J Obstet Gynecol 2008.

Changes in uterine volume before and after insertion of the LNG-IUD

The data were analyzed with the Wilcoxon signed rank test in comparison with the preinsertion value. The most dramatic decrease in uterine volume was noted at 12 months. The volume increased steadily after 12 months; although the volume at 36 months was still less than the initial volume, the difference was statistically insignificant. A significant increase in uterine volume was noted at 36 months compared with 12 months after insertion.

Cho. Levonorgestrel-releasing intrauterine device and adenomyosis. Am J Obstet Gynecol 2008.

Correlations between uterine volume and blood flow in uterine arteries with the use of Pearson’s correlation coefficient

The A, RI, the B, PI, and C, S/D ratio of both uterine arteries had negative correlations with uterine volume.

Cho. Levonorgestrel-releasing intrauterine device and adenomyosis. Am J Obstet Gynecol 2008.