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ObjectiveThe objective of the study was to assess the effectiveness of ultrasound in the antenatal prediction of symptomatic congenital cytomegalovirus (CMV) infection. Study DesignThe sonograms of 650 fetuses from mothers with primary CMV infection were correlated to fetal or neonatal outcome. Infection status was disclosed by viral urine isolation at birth or CMV tissue inclusions at autopsy. Classification of symptomatic disease was based on postnatal clinical or laboratory findings or macroscopic evidence of tissue damage at autopsy. ResultsUltrasound abnormalities were found in 51 of 600 mothers with primary infection (8.5%) and 23 of 154 congenitally infected fetuses (14.9%). Symptomatic congenital infection resulted in 1 of 23 and 68 of 131 cases with or without abnormal sonographic findings, respectively. Positive predictive values of ultrasound vs symptomatic congenital infection was 35.3% relating to all fetuses or infants from mothers with primary infection and 78.3% relating to fetuses or infants with congenital infection. ConclusionWhen fetal infection status is unknown, ultrasound abnormalities predict symptomatic congenital infection in only a third of cases. a Department of Obstetrics and Gynecology, St. Orsola Malpighi Hospital, University of Bologna, Bologna, Italy b Department of Clinical and Experimental Medicine, Section of Microbiology, St. Orsola Malpighi Hospital, University of Bologna, Bologna, Italy c Department of Pediatrics and Neonatology, La Scaletta Hospital, Imola-Bologna, Italy.
Cite this article as: Guerra B, Simonazzi G, Puccetti C, et al. Ultrasound prediction of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol 2008;198:380.e1-380.e7. PII: S0002-9378(07)01196-9 doi:10.1016/j.ajog.2007.09.052 © 2008 Mosby, Inc. All rights reserved.
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ABSTRACT
Ultrasound prediction of symptomatic congenital cytomegalovirus infection
Predicting congenital cytomegalovirus infection: Guerra et al
