American Journal of Obstetrics & Gynecology
Volume 198, Issue 4 , Pages 409.e1-409.e7, April 2008

Body mass index and weight gain prior to pregnancy and risk of gestational diabetes mellitus

Presented as a poster at the 65th Annual Scientific Sessions of the American Diabetes Association, San Diego, CA, June 10-14, 2005.

  • Monique M. Hedderson, MPH, PhD

      Affiliations

    • Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA
    • Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA
    • Corresponding Author InformationReprints: Monique Hedderson, Division of Research, The Kaiser Permanente Medical Group, 2000 Broadway, Oakland, CA 94612-2304.
    • ,
  • Michelle A. Williams, ScD

      Affiliations

    • Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA
    • Center for Perinatal Studies, Swedish Medical Center, Seattle, WA
    • ,
  • Victoria L. Holt, PhD, MPH

      Affiliations

    • Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA
    • Fred Hutchinson Cancer Research Center, Seattle, WA.
    • ,
  • Noel S. Weiss, MD, DrPH

      Affiliations

    • Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA
    • Fred Hutchinson Cancer Research Center, Seattle, WA.
    • ,
  • Assiamira Ferrara, MD, PhD

      Affiliations

    • Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA
    • Department of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, WA

Received 23 February 2007; received in revised form 9 July 2007; accepted 10 September 2007. published online 10 December 2007.

Objective

The objective of the study was to evaluate obesity and rate of weight change during the 5 years before pregnancy and risk of gestational diabetes mellitus (GDM) in a nested case-control study.

Study Design

GDM cases (n = 251) and controls (n = 204) were selected from a multiethnic cohort of 14,235 women who delivered a live birth between 1996 and 1998. Women who gained or lost weight were compared with those with a stable weight (± 1.0 kg/year).

Results

Women who gained weight at a rate of 1.1 to 2.2 kg/year had a small increased risk of GDM (odds ratio [OR] 1.63 [95% confidence interval (CI) 0.95 to 2.81]) and women who gained weight at a rate of 2.3 to 10.0 kg/year had a 2.5-fold increased risk of GDM (OR 2.61 [95% CI, 1.50 to 4.57]), compared with women with stable weight (after adjusting for age, race-ethnicity, parity, and baseline body mass index).

Conclusion

Weight gain in the 5 years before pregnancy may increase the risk of GDM.

Key words: gestational diabetes, obesity, weight gain

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 Cite this article as: Hedderson MM, Williams MA, Holt VL, et al. Body mass index and weight gain prior to pregnancy and risk of gestational diabetes mellitus. Am J Obstet Gynecol 2008;198:409.e1-409.e7.

 This work was supported in part by Grant R01 DK 54834 from the National Institute of Diabetes and Digestive and Kidney Diseases and a research award from the American Diabetes Association.

PII: S0002-9378(07)01127-1

doi:10.1016/j.ajog.2007.09.028

American Journal of Obstetrics & Gynecology
Volume 198, Issue 4 , Pages 409.e1-409.e7, April 2008

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