Metabolic score as a novel approach to assessing preeclampsia risk
Presented at the 27th Annual Clinical Meeting of the Society for Maternal-Fetal Medicine, San Francisco, CA, Feb. 5-10, 2007.
Objective
Clinical trials have confirmed the association of metabolic syndrome with cardiovascular disease (CVD) in women. Because recent evidence suggests that preeclampsia is a risk factor for future CVD, we sought to determine whether metabolic syndrome was associated with preeclampsia.
Study Design
As part of a large case-control study, women were prospectively identified with preeclampsia. Controls were patients presenting for delivery at term without preeclampsia. Two pregnancy-based metabolic scores (0, 1, or 2 or more) were created using initial or final pregnancy body mass index, chronic hypertension, and diabetes. Stratified analysis and logistic regression were used to evaluate the association of metabolic score with preeclampsia and disease severity.
Results
For initial metabolic score, 44.1%, 42.3%, and 13.5% of cases (n = 259) and 61.5%, 33.2%, and 5.3% of controls (n = 297) had scores of 0, 1 (odds ratio [OR] 1.91, P = .002), and 2 or more (OR 2.65, P = .001), respectively.
Conclusion
Metabolic score appears to be associated independently with developing preeclampsia, particularly severe disease.
aDepartment of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA
bDepartment of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Reprints: Michal A. Elovitz, MD, Maternal Fetal Medicine, Department of Obstetrics and Gynecology; CRRWH; University of Pennsylvania, 421 Curie Boulevard, 1353 BRB 2/3, Philadelphia, PA 19104
This work was supported in part by a University of Pennsylvania Research Foundation grant.
Cite this article as: Mazar RM, Srinivas SK, Sammel MD, et al. Metabolic score as a novel approach to assessing preeclampsia risk. Am J Obstet Gynecol 2007;197:411.e1-411.e5.
ABSTRACT