American Journal of Obstetrics & Gynecology
Volume 197, Issue 3 , Pages 250.e1-250.e7 , September 2007

Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition

Presented at the 27th Annual Scientific Meeting of the Society for Maternal-Fetal Medicine, San Francisco, CA, Feb. 5-10, 2007.

  • Sonia S. Hassan, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI
    • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI
    • Corresponding Author InformationReprints: Sonia S. Hassan, MD, and Roberto Romero, MD, Perinatology Research Branch, NICHD, NIH, DHHS, Wayne State University/Hutzel Women’s Hospital, 3990 John R, Box #4, Detroit, MI 48201
    • ,
  • Roberto Romero, MD

      Affiliations

    • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI
    • ,
  • Adi L. Tarca, PhD

      Affiliations

    • Department of Computer Science, Wayne State University, Detroit, MI
    • ,
  • Sorin Draghici, PhD

      Affiliations

    • Department of Computer Science, Wayne State University, Detroit, MI
    • ,
  • Beth Pineles

      Affiliations

    • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI
    • ,
  • Andrej Bugrim, PhD

      Affiliations

    • GeneGo, Inc, St. Joseph, MI.
    • ,
  • Nahla Khalek, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI
    • ,
  • Natalia Camacho, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI
    • ,
  • Pooja Mittal, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI
    • ,
  • Bo Hyun Yoon, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea
    • ,
  • Jimmy Espinoza, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI
    • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI
    • ,
  • Chong Jai Kim, MD, PhD

      Affiliations

    • Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI
    • ,
  • Yoram Sorokin, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI
    • ,
  • John Malone Jr, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI

  • Image Result

    Display of differentially expressed genes in the uterine cervix after term spontaneous labor mapped on the PLAU signaling pathway

    The thermometer represents differentially expressed gene (red indicates

    Display of differentially expressed genes in the uterine cervix after term spontaneous labor mapped on the PLAU signaling pathway

    The thermometer represents differentially expressed gene (red indicates upregulated; blue indicates downregulated). Connectivity analysis results: Several nodes in the PLAU signaling pathway were found to be significant in providing connectivity among the differentially expressed genes. Significant nodes are encircled in red.

    Hassan. Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition. AJOG 2007.

  • Image Result
    Network of transcription factors that activate the expression of PLATHassan. Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term p

    Network of transcription factors that activate the expression of PLAT

    Hassan. Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition. AJOG 2007.

  • Image Result
    JAK1 provides essential network conduit between PLAUR and many differentially expressed targets of STAT1Hassan. Signature pathways identified from gene expression profiles in the human uterine cervix

    JAK1 provides essential network conduit between PLAUR and many differentially expressed targets of STAT1

    Hassan. Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition. AJOG 2007.

  • Image Result
    qRT-PCR results for FGF2, PLAUR, SERPINE2, and LEKT1The boxes encompass 50% of the data from the 1st quartile to the 3rd quartile. The middle line represents the median value (50% quantile). The whisk

    qRT-PCR results for FGF2, PLAUR, SERPINE2, and LEKT1

    The boxes encompass 50% of the data from the 1st quartile to the 3rd quartile. The middle line represents the median value (50% quantile). The whiskers extend to the most extreme data point, but do not exceed which is no >1.5 times the interquartile range from the box.

    Hassan. Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition. AJOG 2007.

 Supported in part by the Intramural Research Program of the National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services. SD has been supported in part by the following grants: NSF DB1-0234806, CCF-0438970, 1RH01HG003491-01A1, 1U01CA117478-01, 1R21CA 100740-01, 1R01NS045207-01, 5R21EB000990-03, 2P30CA022453-24.

 Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the NSF, NIH, DOD, or any other of the funding agencies.

 Cite this article as: Hassan SS, Romero R, Tarca AL, et al. Signature pathways identified from gene expression profiles in the human uterine cervix before and after spontaneous term parturition. Am J Obstet Gynecol 2007;197:250.e1-250.e7.

PII: S0002-9378(07)00875-7

doi: 10.1016/j.ajog.2007.07.008

American Journal of Obstetrics & Gynecology
Volume 197, Issue 3 , Pages 250.e1-250.e7 , September 2007

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