American Journal of Obstetrics & Gynecology
Volume 197, Issue 3 , Pages 267.e1-267.e4 , September 2007

Understanding the mechanism of learning enhancement: NMDA and GABA receptor expression

Presented at the 27th Annual Clinical Meeting of the Society for Maternal-Fetal Medicine, San Francisco, CA, Feb. 5-10, 2007.

Received 13 March 2007 ,Revised 24 April 2007 ,Accepted 31 May 2007.

References 

  1. Toso L, Endres M, Vink J, Abebe DT, Brenneman DE, Spong CY. Learning enhancement with neuropeptides. Am J Obstet Gynecol. 2006;194:1153–1159
  2. Vink J, Auth J, Abebe DT, Brenneman DE, Spong CY. Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome. Am J Obstet Gynecol. 2005;193:825–829
  3. Spong C, Wood L, Poggi S, et al. Postnatal therapy to prevent alcohol-induced learning abnormalities in fetal alcohol syndrome. Am J Obstet Gynecol. 2003;189(suppl):S63
  4. Zhou FC, Sari Y, Powrozek TA, Spong CY. A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth. J Mol Neurosci. 2004;24:189–199
  5. Gozes I, Giladi E, Pinhasov A, Bardea A, Brenneman DE. Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze. J Pharm Exp Ther. 2000;293:1091–1098
  6. Gozes I, Bachar M, Bardea A, et al. Protection against developmental retardation in apolipoprotein E-deficient mice by a fatty neuropeptide: implications for early treatment of Alzheimer's disease. J Neurobiol. 1997;33:329–342
  7. Brenneman DE, Spong CY, Hauser JM, et al. Protective peptides that are orally active and mechanistically nonchiral. J Pharmacol Exp Ther. 2004;309:1190–1197
  8. Toso L, Cameroni I, Schmidt C, Abebe D, Bissell S, Spong CY. Prevention of developmental delays in a down syndrome model. Am J Obstet Gynecol. 2006;195(suppl):S13
  9. Toso L, Poggi SH, Roberson R, et al. Prevention of alcohol-induced learning deficits in fetal alcohol syndrome mediated through NMDA and GABA receptors. Am J Obstet Gynecol. 2006;194:681–686
  10. Toso L, Roberson R, Abebe D, Spong CY. Neuroprotective peptides prevent some alcohol-induced alteration in GABAβ3 which plays a role in cleft lip and palate and learning in fetal alcohol syndrome. Am J Obstet Gynecol. 2007;196:259;e1-259.e5
  11. Sucher NJ, Awobuluyi M, Choi YB, Lipton SA. NMDA receptors: from genes to channels. Trends Pharmacol Sci. 1996;17:348–355
  12. Freund TF, Buzsàki G. Interneurons of the hippocampus. Hippocampus. 1996;6:347–470
  13. Morris RGM. Long-term potentiation and memory. Phil Trans R Soc Lond. 2003;358:643–647
  14. Perez-Otano I, Ehlers MD. Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses. Neurosignals. 2004;13:175–189
  15. Barker JL, Behar T, Li YX, et al. GABAergic cells and signals in CNS development. Perspect Dev Neurobiol. 1998;5:305–322
  16. Mehta AK, Ticku M. An update on GABAA receptors. Brain Res. 1999;29:196–217
  17. Zhang TA, Hendricson AW, Wilkemeyer MF, Lippmann MJ, Charness ME, Morrisett RA. Synergistic effects of the peptide fragment D-NAPVSIPQ on ethanol inhibition of synaptic plasticity and NMDA receptors in rat hippocampus. Neuroscience. 2005;134:583–593
  18. Boehm SL, Ponomarev I, Jennings AW, et al. Gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions. Biochem Pharmacol. 2004;68:1581–1602
  19. Divinski I, Mittelman L, Gozes I. A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication. J Biol Chem. 2004;27:28531–28538
  20. White D, Walker S, Brenneman DE, Gozes I. CREB contributes to the increased neurite outgrowth of sensory neurons induced by vasoactive intestinal peptide and activity-dependent neurotrophic factor. Brain Res. 2000;868:31–38
  21. Glazner GW, Boland A, Dresse AE, Brenneman DE, Gozes I, Mattson MP. Activity-dependent neurotrophic factor peptide (ADNF9) protects neurone against oxidative stress-induced death. J Neurochem. 1999;73:2341–2347
  22. Spong CY, Abebe DT, Gozes I, Brenneman DE, Hill JM. Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. J Pharmacol Exp Ther. 2001;297:774–779

 Supported by the Intramural Research Program of the National Institute of Child Health and Human Development and the Intramural Research Program of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD.

 Cite this article as: Toso L, Johnson A, Bissell S, Roberson R, Abebe D, Spong CY. Understanding the mechanism of learning enhancement: NMDA and GABA receptor expression. Am J Obstet Gynecol 2007;197:267.e1-267.e4.

PII: S0002-9378(07)00719-3

doi: 10.1016/j.ajog.2007.05.049

American Journal of Obstetrics & Gynecology
Volume 197, Issue 3 , Pages 267.e1-267.e4 , September 2007

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