American Journal of Obstetrics & Gynecology
Volume 197, Issue 2 , Pages 160.e1-160.e5 , August 2007

Frontomaxillary facial angles in screening for trisomy 21 at 14-23 weeks’ gestation

  • Jiri Sonek, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wright State University, Dayton, OH
    • Fetal Medicine Foundation/USA, Dayton, OH.
    • ,
  • Marisa Borenstein, MD

      Affiliations

    • Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital, London, UK
    • ,
  • Cathy Downing, RT, RDMS, RVT

      Affiliations

    • Fetal Medicine Foundation/USA, Dayton, OH.
    • ,
  • David McKenna, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wright State University, Dayton, OH
    • Fetal Medicine Foundation/USA, Dayton, OH.
    • ,
  • Ran Neiger, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wright State University, Dayton, OH
    • Fetal Medicine Foundation/USA, Dayton, OH.
    • ,
  • Christopher Croom, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wright State University, Dayton, OH
    • Fetal Medicine Foundation/USA, Dayton, OH.
    • ,
  • Toby Genrich, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Wright State University, Dayton, OH
    • ,
  • Kypros H. Nicolaides, MD

      Affiliations

    • Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital, London, UK
    • Corresponding Author InformationReprints: Professor K. H. Nicolaides, Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital Medical School, Denmark Hill, London SE5 8RX, UK.

Received 7 November 2006 ,Revised 4 January 2007 ,Accepted 13 March 2007.

References 

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  6. Dagklis T, Borenstein M, Peralta CFA, Faro C, Nicolaides KH. Three-dimensional evaluation of mid-facial hypoplasia in fetuses with trisomy 21 at 11-13+6 weeks. Ultrasound Obstet Gynecol. 2006;28:261–265
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  8. Sonek J, Borenstein M, Dagklis T, Persico N, Nicolaides K. Frontomaxillary facial angle in fetuses with trisomy 21 at 11-13+6 weeks. Am J Obstet Gynecol. 2007;196:271.e1–271.e4
  9. Maymon R, Levinsohn-Tavor O, Cuckle H, Tovbin Y, et al. Second trimester ultrasound prenasal thickness combined with nasal bone length: a new method of Down syndrome screening. Prenat Diagn. 2005;25:906–911
  10. Sonek J, Nicolaides K. Prenatal ultrasound diagnosis of nasal bone abnormalities in three fetuses with Down syndrome. Am J Obstet Gynecol. 2002;186:139–141
  11. Cicero S, Curcio P, Papageorghiou A, Sonek J, Nicolaides KH. Absence of nasal bone in fetuses with trisomy 21 at 11-14 weeks of gestation: an observational study. Lancet. 2001;358:1665–1667
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  14. Snijders RJ, Noble P, Sebire N, Souka A, Nicolaides KH. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation (Fetal Medicine Foundation First Trimester Screening Group). Lancet. 1998;352:343–346
  15. Nicolaides KH. Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities. Am J Obstet Gynecol. 2004;191:45–67
  16. Benacerraf BR, Gelman R, Frigoletto FD. Sonographic identification of second trimester fetuses with Down’s syndrome. N Engl J Med. 1987;317:1371–1376
  17. Sonek J, Cicero S, Neiger R, Nicolaides K. Nasal bone assessment in prenatal screening for trisomy 21. Am J Obstet Gynecol. 2006;195:1219–1230

 Cite this article as: Sonek J, Borenstein M, Downing C, et al. Frontomaxillary facial angles in screening for trisomy 21 at 14-23 weeks’ gestation. Am J Obstet Gynecol 2007;197:160.e1-160.e5.

PII: S0002-9378(07)00425-5

doi: 10.1016/j.ajog.2007.03.059

American Journal of Obstetrics & Gynecology
Volume 197, Issue 2 , Pages 160.e1-160.e5 , August 2007

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