Frontomaxillary facial angles in screening for trisomy 21 at 14-23 weeks’ gestation
Received 7 November 2006; received in revised form 4 January 2007; accepted 13 March 2007.
Objective
The objective of the study was to investigate the potential value of the frontomaxillary facial (FMF) angle in second-trimester ultrasound screening for trisomy 21.
Methods
We examined stored images of fetal profiles taken before amniocentesis at 14-24 weeks from 100 euploid fetuses and 34 with trisomy 21. The FMF angles between the upper surface of the upper palate and the frontal bone (FMFbone) and the skin over the forehead (FMFskin) were measured.
Results
In the euploid group the FMF angles decreased with gestation. In the fetuses with trisomy 21, the FMFbone and FMFskin angles were 79.4% and 87.9% above the 95th percentile for gestation of the respective values from the euploid group. In trisomy 21 fetuses, there was no significant difference in FMF angles between those with nasal bone hypoplasia (n = 19) and those without (n = 15).
Conclusion
The FMF angle is substantially higher in trisomy 21 than euploid fetuses. Measurement of the FMF angles is likely to prove a useful method in prenatal screening for trisomy 21 in the second trimester.
Reprints: Professor K. H. Nicolaides, Harris Birthright Research Centre for Fetal Medicine, King’s College Hospital Medical School, Denmark Hill, London SE5 8RX, UK.
Cite this article as: Sonek J, Borenstein M, Downing C, et al. Frontomaxillary facial angles in screening for trisomy 21 at 14-23 weeks’ gestation. Am J Obstet Gynecol 2007;197:160.e1-160.e5.
ABSTRACT