Chorionic villus sampling and risk for hypertensive disorders of pregnancy
Presented at the 73rd Annual Meeting of the Pacific Coast Obstetrical and Gynecological Society, Sun Valley, ID, Oct. 4-8, 2006.
Received 31 August 2006; received in revised form 30 November 2006; accepted 2 March 2007.
Objective
This study was undertakin to evaluate the relationship between chorionic villus sampling at 10-13 weeks’ gestational age and hypertensive disorders of pregnancy.
Study Design
The prevalence of hypertensive disorders of pregnancy in women with singleton gestations, undergoing transcervical or transabdominal chorionic villus sampling between 10 weeks 0 days’ and 13 weeks 6 days’ gestational age was compared with that of control women with singleton gestations having first-trimester screening with nuchal translucency and biochemistry between 11 weeks 0 days’ and 13 weeks 6 days’ gestational age. Patients having invasive prenatal diagnosis (chorionic villus sampling or amniocentesis) were excluded from the control group. All patients delivered at Cedars-Sinai Medical Center.
Results
There were 1540 women who had chorionic villus sampling and 840 controls. Hypertensive disorders of pregnancy were diagnosed in 76 (4.9%) patients in the chorionic villus sampling group and in 37 (4.4%) of the controls (χ2 = 0.34, P = .31).
Conclusion
Chorionic villus sampling at 10 to 13 weeks’ gestational age does not appear to increase the overall risk for hypertensive disorders of pregnancy. However, there appears to be an association between chorionic villus sampling and severe hypertensive disorders including severe preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, and low platelet count syndrome.
1Division of Maternal-Fetal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA
2Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA
3David Geffen School of Medicine, University of California, Los Angeles, CA
4Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI.
Reprints: Jasvant Adusumalli, MD, Department of Obstetrics/Gynecology, Division of Maternal-Fetal Medicine, 8635 W. 3rd St, Suite 160W, Los Angeles, CA 90048
Cite this article as: Adusumalli J, Han CS, Beckham S, Bartholomew ML, Williams J III. Chorionic villus sampling and risk for hypertensive disorders of pregnancy. Am J Obstet Gynecol 2007;196:591.e1-591.e7.
ABSTRACT