American Journal of Obstetrics & Gynecology
Volume 196, Issue 5 , Pages 457.e1-457.e6 , May 2007

The effect of a prolonged time interval between antenatal corticosteroid administration and delivery on outcomes in preterm neonates: a cohort study

  • Allison M. Ring, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical College of Wisconsin Affiliated Hospitals, St. Joseph Regional Medical Center, Milwaukee, WI
    • ,
  • Jeffery S. Garland, MD, SM

      Affiliations

    • Department of Pediatrics, St. Joseph Regional Medical Center, Milwaukee, WI
    • ,
  • Brian R. Stafeil, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical College of Wisconsin Affiliated Hospitals, St. Joseph Regional Medical Center, Milwaukee, WI
    • ,
  • Margaret H. Carr, MD

      Affiliations

    • Center for Obstetrical Research and Education, St. Joseph Regional Medical Center, Milwaukee, WI.
    • ,
  • Gail S. Peckman, MS

      Affiliations

    • Center for Obstetrical Research and Education, St. Joseph Regional Medical Center, Milwaukee, WI.
    • ,
  • Richard A. Pircon, MD

      Affiliations

    • Center for Obstetrical Research and Education, St. Joseph Regional Medical Center, Milwaukee, WI.

References 

  1. Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics. 1972;50:515–525
  2. Crowley PA, Chalmers I, Kierse MJ. The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. BJOG. 1990;97:11–25
  3. Vermillion ST, Soper DE, Newman RB. Is betamethasone effective longer than 7 days after treatment?. Obstet Gynecol. 2001;97:491–493
  4. Sehdev HM, Abbasi S, Robertson P, et al. The effects of the time interval from antenatal corticosteroid exposure to delivery on neonatal outcome of very low birth weight infants. Am J Obstet Gynecol. 2004;191:1409–1413
  5. Peaceman AM, Bajaj K, Kumar P, Grobman WA. The interval between a single course of antenatal steroids and delivery and its association with neonatal outcomes. Am J Obstet Gynecol. 2005;193:1165–1169
  6. Garite TJ, Rumney PJ, Briggs GG, et al. A randomized, placebo-controlled trial of betamethasone for the prevention of respiratory distress syndrome at 24 to 28 weeks’ gestation. Am J Obstet Gynecol. 1992;166:646–651
  7. Papile L, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1500 grams. J Pediatr. 1978;92:529–534
  8. Guinn D, Atkinson MW, Sullivan L, et al. Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: a randomized controlled trial. JAMA. 2001;286:1581–1587
  9. National Institutes of Health Consensus Development. conference statement on the effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA. 1995;273:413–418
  10. French N, Hagan R, Evans S, Godfrey M, Newnham J. Repeated antenatal corticosteroids: size at birth and subsequent development. Am J Obstet Gynecol. 1999;180:114–121
  11. National Institutes of Health Consensus Development Panel. Antenatal corticosteroids revisited: repeat courses: National Institutes of Health Consensus Development Conference Statement, August 17-18, 2000. Obstet Gynecol. 2001;98:144–150
  12. Vidaeff AC, Ramin SM, Gilstrap LC, Alcorn JL. Characterization of corticosteroid redosing in an in vitro cell line model. Am J Obstet Gynecol. 2004;191:1403–1408
  13. McEvoy C, Bowling S, Williamson K, Collins J, Tolaymat L, Maher J. Timing of antenatal corticosteroids and neonatal pulmonary mechanics. Am J Obstet Gynecol. 2000;183:895–899

 Cite this article as: Ring AM, Garland JS, Stafeil BR, et al. The effect of a prolonged time interval between antenatal corticosteroid administration and delivery on outcomes in preterm neonates: a cohort study. Am J Obstet Gynecol 2007;196:457.e1-457.e6.Reprints not available from the authors.

PII: S0002-9378(06)02435-5

doi: 10.1016/j.ajog.2006.12.018

American Journal of Obstetrics & Gynecology
Volume 196, Issue 5 , Pages 457.e1-457.e6 , May 2007

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