American Journal of Obstetrics & Gynecology
Volume 196, Issue 1 , Pages 31.e1-31.e7 , January 2007

Bleeding patterns after misoprostol vs surgical treatment of early pregnancy failure: results from a randomized trial

  • Anne R. Davis, MD

      Affiliations

    • Columbia University, New York, NY
    • Corresponding Author InformationReprint requests: Anne R. Davis, MD, Columbia University, Department of Obstetrics & Gynecology, 622 West 168th St, PH 16 Room 80, New York, NY 10032
    • ,
  • Sarah K. Hendlish, MPH

      Affiliations

    • Columbia University, New York, NY
    • ,
  • Carolyn Westhoff, MD

      Affiliations

    • Columbia University, New York, NY
    • ,
  • Margaret M. Frederick, PhD, MD

      Affiliations

    • Clinical Trials and Surveys Corp, Baltimore, MD
    • ,
  • Jun Zhang, PhD, MD

      Affiliations

    • National Institute of Child Health and Human Development, National Institutes of Health, Division of Health and Human Services, Bethesda, MD
    • ,
  • Jerry M. Gilles, MD

      Affiliations

    • University of Miami, Miami, FL
    • ,
  • Kurt Barnhart, MD, MSCE

      Affiliations

    • Penn Fertility Care and the Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    • ,
  • Mitchell D. Creinin, MD

      Affiliations

    • University of Pittsburgh and McGee Women’s Research Institute, Pittsburgh, PA.
    • ,
  • National Institute of Child Health and Human Development Management of Early Pregnancy Failure Trial

Received 1 February 2006 ,Accepted 5 July 2006.

References 

  1. Alberman E. Spontaneous abortions: Epidemiology. In:  Stabile GG,  Hard T editor. Spontaneous abortion: Diagnosis and treatment. London: Springer Verlag; 1992;p. 19–20
  2. Zhang J, Gilles JM, Barnhart K, Creinin MD, Westhoff C, Frederick MM. A comparison of medical management with misoprostol and surgical management for early pregnancy failure. N Engl J Med. 2005;353:761–769
  3. Chia KV, Ogbo VI. Medical termination of missed abortion. J Obstet Gynaecol. 2002;22:184–186
  4. Chung TK, Lee DT, Cheung LP, Haines CJ, Chang AM. Spontaneous abortion: A randomized, controlled trial comparing surgical evacuation with conservative management using misoprostol. Fertil Steril. 1999;71:1054–1059
  5. de Jonge ET, Makin JD, Manefeldt E, De Wet GH, Pattinson RC. Randomised clinical trial of medical evacuation and surgical curettage for incomplete miscarriage. BMJ. 1995;311:662
  6. Demetroulis C, Saridogan E, Kunde D, Naftalin AA. A prospective randomized control trial comparing medical and surgical treatment for early pregnancy failure. Hum Reprod. 2001;16:365–369
  7. Graziosi GC, Mol BW, Reuwer PJ, Drogtrop A, Bruinse HW. Misoprostol versus curettage in women with early pregnancy failure after initial expectant management: A randomized trial. Hum Reprod. 2004;19:1894–1899
  8. Gronlund A, Gronlund L, Clevin L, Andersen B, Palmgren N, Lidegaard O. Management of missed abortion: Comparison of medical treatment with either mifepristone + misoprostol or misoprostol alone with surgical evacuation: A multi-center trial in Copenhagen county, Denmark. Acta Obstet Gynecol Scand. 2002;81:1060–1065
  9. Gronlund L, Gronlund A, Clevin L, Andersen B, Palmgren N, Lidegaard O. Spontaneous abortion: Expectant management, medical treatment or surgical evacuation. Acta Obstet Gynecol Scand. 2002;81:781–782
  10. Muffley PE, Stitely ML, Gherman RB. Early intrauterine pregnancy failure: A randomized trial of medical versus surgical treatment. Am J Obstet Gynecol. 2002;187:321–325
  11. Sahin HG, Sahin HA, Kocer M. Randomized outpatient clinical trial of medical evacuation and surgical curettage in incomplete miscarriage. Eur J Contracept Reprod Health Care. 2001;6:141–144
  12. Shelley JM, Healy D, Grover S. A randomised trial of surgical, medical and expectant management of first trimester spontaneous miscarriage. Aust N Z J Obstet Gynaecol. 2005;45:122–127
  13. Weeks A, Alia G, Blum J, et al. A randomized trial of misoprostol compared with manual vacuum aspiration for incomplete abortion. Obstet Gynecol. 2005;106:540–547
  14. Davis AR, Robilotto CM, Westhoff CL, Forman S, Zhang J. For the NICHD Management of Early Pregnancy Failure Trial group: Bleeding patterns after vaginal misoprostol for treatment of early pregnancy failure. Hum Reprod. 2004;19:1655–1658
  15. Blanchard K, Taneepanichskul S, Kiriwat O, et al. Two regimens of misoprostol for treatment of incomplete abortion. Obstet Gynecol. 2004;103:860–865
  16. Ngai SW, Chan YM, Tang OS, Ho PC. Vaginal misoprostol as medical treatment for first trimester spontaneous miscarriage. Hum Reprod. 2001;16:1493–1496
  17. Tang OS, Lau WN, Ng EH, Lee SW, Ho PC. A prospective randomized study to compare the use of repeated doses of vaginal with sublingual misoprostol in the management of first trimester silent miscarriages. Hum Reprod. 2003;18:176–181
  18. Creinin MD, Moyer R, Guido R. Misoprostol for medical evacuation of early pregnancy failure. Obstet Gynecol. 1997;89:768–772
  19. Henshaw RC, Cooper K, El-Refaey H, Smith NC, Templeton AA. Medical management of miscarriage: Non-surgical uterine evacuation of incomplete and inevitable spontaneous abortion. BMJ. 1993;306:894–895
  20. Davis AR, Westhoff C, De Nonno L. Bleeding patterns after early abortion with mifepristone and misoprostol or manual vacuum aspiration. J Am Med Womens Assoc. 2000;55(suppl):141–144

 Funded by contracts (N01-HD-1-3321, N01-HD-3322, N01-HD-3323, N01-HD-3324, and N01-HD-3325) with the National Institute of Child Health and Human Development, National Institutes of Health.Cite this article as: Davis AR, Hendlish SK, Westhoff C, et al. Bleeding patterns after misoprostol vs surgical treatment of early pregnancy failure: results from a randomized trial. Am J Obstet Gynecol 2007;196:31.e1-31.e7.

PII: S0002-9378(06)01154-9

doi: 10.1016/j.ajog.2006.07.053

American Journal of Obstetrics & Gynecology
Volume 196, Issue 1 , Pages 31.e1-31.e7 , January 2007

Article Tools

* Image Usage & Resolution