American Journal of Obstetrics & Gynecology
Volume 195, Issue 4 , Pages 1153-1157 , October 2006

Antenatal noninvasive treatment of patients at risk for alloimmune thrombocytopenia without a history of intracranial hemorrhage

  • Yoav Yinon, MD

      Affiliations

    • Department of Obstetrics and Gynecology, the Chaim Sheba Medical Center
    • Corresponding Author InformationReprint requests: Yoav Yinon MD, Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel.
    • ,
  • Maya Spira, MD

      Affiliations

    • Department of Obstetrics and Gynecology, the Chaim Sheba Medical Center
    • ,
  • Ofira Solomon, MD

      Affiliations

    • Department of Hematology, Amalia Biron Research Institute of Thrombosis and Hemostasis, the Chaim Sheba Medical Center, Tel-Hashomer, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    • ,
  • Boaz Weisz, MD

      Affiliations

    • Department of Obstetrics and Gynecology, the Chaim Sheba Medical Center
    • ,
  • Benjamin Chayen, MD

      Affiliations

    • Department of Obstetrics and Gynecology, the Chaim Sheba Medical Center
    • ,
  • Eyal Schiff, MD

      Affiliations

    • Department of Obstetrics and Gynecology, the Chaim Sheba Medical Center
    • ,
  • Shlomo Lipitz, MD

      Affiliations

    • Department of Obstetrics and Gynecology, the Chaim Sheba Medical Center

Received 9 March 2006 ,Revised 31 May 2006 ,Accepted 17 June 2006.

References 

  1. Pearson HA, Shulman NR, Marder VJ, Cone TE. Isoimmune neonatal thrombocytopenic purpura: clinical and therapeutic considerations. Blood. 1964;23:154–177
  2. Williamson LM, Hackett G, Rennie J, Palmer C, Maciver C, Hadfield R, et al. The natural history of fetomaternal alloimmunization to the platelet-specific antigen HPA-1a as determined by antenatal screening. Blood. 1998;92:2280–2287
  3. Blanchette VS, Chen I, de Friedberg ZS, Hogan VA, Trudel E, Decary F. Alloimmunization to the PLA1 platelet antigen: results of a prospective study. Br J Haematol. 1990;74:209–215
  4. Mueller-Eckhardt C, Kiefel V, Grubert A, Kroll H, Weisheit M, Schmidt S, et al. 348 cases of suspected neonatal alloimmune thrombocytopenia. Lancet. 1989;1:363–366
  5. Herman JH, Jumbelic MI, Ancona RJ, Kickler TS. In utero cerebral hemorrhage in alloimmune thrombocytopenia. Am J Pediatr Hematol Oncol. 1986;8:312–317
  6. Burrows RF, Kelton JG. Fetal thrombocytopenia and its relation to maternal thrombocytopenia. N Engl J Med. 1993;329:1463–1466
  7. Bussel JB, Zabusky BA, Berkowitz RL, McFarland JG. Fetal alloimmune thrombocytopenia. N Engl J Med. 1997;337:22–26
  8. Murphy MF, Waters AH, Doughty HA, Hambley H, Mibashan RS, Nicolaides K, et al. Antenatal management of fetal alloimmune thrombocytopenia: report of 15 affected pregnancies. Transfus Med. 1994;4:281–292
  9. Kaplan C, Murphy MF, Kroll H, Waters AH. Feto-maternal alloimmune thrombocytopenia: antenatal therapy with IvIgG and steroids- more questions than answers. Br J Haematol. 1998;100:62–65
  10. Lynch L, Bussel JB, McFarland JG, Chitkara U, Berkowitz RL. Antenatal treatment of alloimmune thrombocytopenia. Obstet Gynecol. 1992;80:67–71
  11. Gyamfi C, Eddleman KA. Alloimmune thrombocytopenia. Clin Obstet Gynecol. 2005;48:897–909
  12. Buscaglia M, Ghisoni L, Bellotti M, Ferrazzi E, Levi-Setti P, Marconi AM, et al. Percutaneous umbilical blood sampling: indication changes and procedure loss rate in a nine years' experience. Fetal Diagn Ther. 1996;11:106–113
  13. Bussel JB, Berkowitz RL, McFarland JG, Lynch L, Chitkara U. Antenatal treatment of neonatal alloimmune thrombocytopenia. N Engl J Med. 1988;319:1374–1378
  14. Paidas MJ, Berkowitz RL, Lynch L, Lockwood CJ, Lapinski R, McFarland JG. Alloimmune thrombocytopenia: fetal and neonatal losses related to cordocentesis. Am J Obstet Gynecol. 1995;172:475–479
  15. Silver RM, Porter TF, Branch DW, Esplin MS, Scott JR. Neonatal alloimmune thrombocytopenia: antenatal management. Am J Obstet Gynecol. 2000;182:1233–1238
  16. Radder CM, Brand A, Kanhai HH. A less invasive treatment strategy to prevent intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia. Am J Obstet Gynecol. 2001;185:683–688
  17. Berkowitz RL, Kolb EA, McFarland JG, Wissert M, Primani A, Lesser M, et al. Parallel randomized trials of risk-based therapy for fetal alloimmune thrombocytopenia. Obstet Gynecol. 2006;107:91–96
  18. Bussel JB, Berkowitz RL, Lynch L, Lesser ML, Paidas MJ, Huang CL, et al. Antenatal management of alloimmune thrombocytopenia with intravenous gamma globulin: a randomized trial of the addition of low dose steroid to intravenous gamma globulin. Am J Obstet Gynecol. 1996;174:1414–1423

 Presented at the 26th Annual Meeting of the Society for Maternal Fetal Medicine, January 30-February 4, 2006, Miami, Florida.

PII: S0002-9378(06)00822-2

doi: 10.1016/j.ajog.2006.06.066

American Journal of Obstetrics & Gynecology
Volume 195, Issue 4 , Pages 1153-1157 , October 2006

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