American Journal of Obstetrics & Gynecology
Volume 195, Issue 3 , Pages 822-828 , September 2006

Uterine transcriptomes of bacteria-induced and ovariectomy-induced preterm labor in mice are characterized by differential expression of arachidonate metabolism genes

  • Ramsi Haddad, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • ,
  • Barbara R. Gould, PhD

      Affiliations

    • Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada
    • ,
  • Roberto Romero, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
    • ,
  • Gerard Tromp, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
    • ,
  • Riaz Farookhi, PhD

      Affiliations

    • Department of Physiology, McGill University, Montréal, Québec, Canada
    • ,
  • Sam S. Edwin, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • ,
  • Mi Ran Kim, MS

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • ,
  • Hans H. Zingg, MD, PhD

      Affiliations

    • Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada

Received 10 March 2006 ,Revised 25 May 2006 ,Accepted 15 June 2006.

References 

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  3. Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med. 2003;348:2379–2385
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  11. Tromp G, Kuivaniemi H, Romero R, Chaiworapongsa T, Kim YM, Kim MR, et al. Genome-wide expression profiling of fetal membranes reveals a deficient expression of proteinase inhibitor 3 in premature rupture of membranes. Am J Obstet Gynecol. 2004;191:1331–1338
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  15. Romero R, Quintero R, Emamian M, Wan M, Grzyboski C, Hobbins JC, et al. Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor. Am J Obstet Gynecol. 1987;157:1454–1460
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  21. Wetzka B, Schafer W, Scheibel M, Nusing R, Zahradnik HP. Eicosanoid production by intrauterine tissues before and after labor in short-term tissue culture. Prostaglandins. 1993;45:571–581
  22. Faber BM, Metz SA, Chegini N. Immunolocalization of eicosanoid enzymes and growth factors in human myometrium and fetoplacental tissues in failed labor inductions. Obstet Gynecol. 1996;88:174–179
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  25. Hirsch E, Muhle RA, Mussalli GM, Blanchard R. Bacterially induced preterm labor in the mouse does not require maternal interleukin-1 signaling. Am J Obstet Gynecol. 2002;186:523–530

 Supported in part by the Intramural Research Program of the National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services.Presented at the 26th Annual Meeting of the Society for Maternal Fetal Medicine, January 30-February 4, 2006, Miami, FL.Reprints not available. Address correspondence to Roberto Romero, MD, Hutzel Women's Hospital, 3990 John R, 4th Floor, Detroit, MI 48201-2018 or Ramsi Haddad, PhD, Translational Oncogenomics Laboratory, Karmanos Cancer Institute, Detroit, MI 48201.

PII: S0002-9378(06)00808-8

doi: 10.1016/j.ajog.2006.06.053

American Journal of Obstetrics & Gynecology
Volume 195, Issue 3 , Pages 822-828 , September 2006

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