American Journal of Obstetrics & Gynecology
Volume 194, Issue 4 , Pages 947.e1-947.e10 , April 2006

Associations between fetal inherited thrombophilia and adverse pregnancy outcomes

  • Catherine S. Gibson, PhD

      Affiliations

    • Department of Obstetrics and Gynaecology, The University of Adelaide
    • Department of Microbiology and Infectious Diseases, Women's and Children's Hospital, Adelaide, South Australia
    • Corresponding Author InformationReprint requests: Dr Catherine S. Gibson, The University of Adelaide Department of Obstetrics and Gynaecology, Women's and Children's Hospital, 1st Floor Queen Victoria Building, 72 King William Road, North Adelaide 5006, Adelaide, South Australia.
    • ,
  • Alastair H. MacLennan, MD

      Affiliations

    • Department of Obstetrics and Gynaecology, The University of Adelaide
    • ,
  • Nard G. Janssen

      Affiliations

    • Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • Willem J. Kist

      Affiliations

    • Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    • ,
  • William M. Hague, MD

      Affiliations

    • Department of Obstetrics and Gynaecology, The University of Adelaide
    • ,
  • Eric A. Haan, MBBS

      Affiliations

    • Department of Genetic Medicine, Women's and Children's Hospital
    • Department of Paediatrics, The University of Adelaide, Adelaide, South Australia
    • ,
  • Paul N. Goldwater, MBBS

      Affiliations

    • Department of Microbiology and Infectious Diseases, Women's and Children's Hospital, Adelaide, South Australia
    • Department of Paediatrics, The University of Adelaide, Adelaide, South Australia
    • ,
  • Kevin Priest, BSc

      Affiliations

    • Epidemiology Branch, Department of Health
    • ,
  • Gustaaf A. Dekker, PhD

      Affiliations

    • Department of Obstetrics and Gynaecology, The University of Adelaide
    • ,
  • for the South Australian Cerebral Palsy Research Group

Received 24 November 2005 ,Revised 19 January 2006 ,Accepted 31 January 2006.

References 

  1. Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol. 2004;191:412–424
  2. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med. 2001;344:1222–1231
  3. Dizon-Townson D, Meline L, Nelson L, Varner M, Ward K. Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction. Am J Obstet Gynecol. 1997;177:402–405
  4. Isotalo PA, Wells GA, Donnelly JG. Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations. Am J Hum Genet. 2000;67:986–990
  5. von Kries R, Junker R, Oberle D, Kosch A, Nowak-Gottl U. Foetal growth restriction in children with prothrombotic risk factors. Thromb Haemost. 2001;86:1012–1016
  6. Infante-Rivard C, Rivard GE, Yotov WV, Genin E, Guiguet M, Weinberg C, et al. Absence of association of thrombophilia polymorphisms with intrauterine growth restriction. N Engl J Med. 2002;347:19–25
  7. Glanville T, Yates Z, Ovadia L, Walker J, Lucock M, Simpson N. Fetal carriage of folate gene polymorphisms C677T methylenetetrahydrofolate reductase and A2756G methionine synthase are not related to fetal growth restriction. Am J Obstet Gynecol. 2002;187:S184
  8. McCowan LM, Craigie S, Taylor RS, Ward C, McLintock C, North RA. Inherited thrombophilias are not increased in “idiopathic” small-for-gestational-age pregnancies. Am J Obstet Gynecol. 2003;188:981–985
  9. Anteby EY, Musalam B, Milwidsky A, Blumenfeld A, Gilis S, Valsky D, et al. Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption. Eur J Obstet Gynecol Reprod Biol. 2004;113:31–35
  10. Dekker JW, Lind J, Bloemenkamp KW, Quint WG, Kuijpers JC, van Doorn LJ, et al. Inherited risk of thrombosis of the fetus and intrauterine fetal death. Eur J Obstet Gynecol Reprod Biol. 2004;117:45–48
  11. Gibson CS, Maclennan AH, Hague WM, Haan EA, Priest K, Chan A, et al. Associations between inherited thrombophilias, gestational age, and cerebral palsy. Am J Obstet Gynecol. 2005;193:1437;e1-1437 e12
  12. Roberts CL, Lancaster PA. Australian national birthweight percentiles by gestational age. Med J Aust. 1999;170:114–118
  13. Walker I. Thrombophilia in pregnancy. J Clin Pathol. 2000;53:573–580
  14. Higgins J. Pregnancy and the impact of inherited thrombophilias. Aust N Z J Obstet Gynaecol. 2000;40:118–121
  15. Rosendaal F, Koster T, Vandenbrouke J, Reitsma P. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein resistance). Blood. 1995;85:1504–1508
  16. Gopel W, Kim D, Gortner L. Prothrombotic mutations as a risk factor for preterm birth. Lancet. 1999;353:1411–1412
  17. Jacques P, Bostom A, Williams R. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7–9
  18. Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest. 1986;77:1909–1916
  19. Welch G, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042–1051
  20. Van der Put N, Gabreels E, Smeitink J. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet. 1998;62:1044–1051
  21. Nurk E, Tell GS, Refsum H, Ueland PM, Vollset SE. Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine Study. Am J Med. 2004;117:26–31
  22. Heard AR, Dekker GA, Chan A, Jacobs DJ, Vreeburg SA, Priest KR. Hypertension during pregnancy in South Australia, part 1: pregnancy outcomes. Aust N Z J Obstet Gynaecol. 2004;44:404–409

 Supported by The Australian National Health and Medical Research Council, The Channel 7 Children's Research Foundation, The University of Adelaide, and The South Australian Government Captive Insurance Corporation. The supporting sources had no influence on the analysis, writing, or submission of the manuscript.Presented at the 26th Annual Meeting of the Society for Maternal Fetal Medicine, Miami, FL, January 30-February 4, 2006.Supplementary material available at: www.ajog.org.

PII: S0002-9378(06)00186-4

doi: 10.1016/j.ajog.2006.01.111

American Journal of Obstetrics & Gynecology
Volume 194, Issue 4 , Pages 947.e1-947.e10 , April 2006

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