American Journal of Obstetrics & Gynecology
Volume 194, Issue 2 , Pages 397-401 , February 2006

Sonographic screening for trisomy 13 at 11 to 13+6 weeks of gestation

  • Aris T. Papageorghiou, MD

      Affiliations

    • Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, United Kingdom
    • ,
  • Kyriaki Avgidou, MD

      Affiliations

    • Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, United Kingdom
    • ,
  • Kevin Spencer, DSc

      Affiliations

    • Prenatal Screening Unit, Department of Clinical Biochemistry, Harold Wood Hospital, Gubbins Lane, Essex, United Kingdom
    • ,
  • Barry Nix, PhD

      Affiliations

    • Department of Epidemiology, Statistics and Public Health, Cardiff University, Cardiff, United Kingdom
    • ,
  • Kypros H. Nicolaides, MD

      Affiliations

    • Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, United Kingdom
    • Corresponding Author InformationReprint requests: K. H. Nicolaides, MD, Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London SE5 8RX.

Received 12 April 2005 ,Revised 6 May 2005 ,Accepted 4 August 2005.

References 

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  2. Snijders RJ, Sebire NJ, Nicolaides KH. Maternal age and gestational age-specific risk for chromosomal defects. Fetal Diagn Ther. 1995;10:356–367
  3. Rasmussen SA, Wong LY, Yang Q, May KM, Friedman JM. Population-based analyses of mortality in trisomy 13 and trisomy 18. Pediatrics. 2003;111:777–784
  4. Snijders RMJ, Noble P, Sebire N, Souka A, Nicolaides KH. UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal translucency thickness at 10-14 weeks of gestation. Lancet. 1998;351:343–346
  5. Snijders RJ, Sebire NJ, Nayar R, Souka A, Nicolaides KH. Increased nuchal translucency in trisomy 13 fetuses at 10-14 weeks of gestation. Am J Med Genet. 1999;86:205–207
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  13. Snidjers RJM, Sebire NJ, Souka A, Santiago C, Nicolaides KH. Fetal exomphalos and chromosomal defects: relationship to maternal age and gestation. Ultrasound Obstet Gynecol. 1995;6:250–255
  14. Sebire NJ, von Kaisenberg C, Rubio C, Snijders RJM, Nicolaides KH. Fetal megacystis at 10-14 weeks of gestation. Ultrasound Obstet Gynecol. 1996;8:387–390
  15. Liao AW, Sebire NJ, Geerts L, Cicero S, Nicolaides KH. Megacystis at 10-14 weeks of gestation: chromosomal defects and outcome according to bladder length. Ultrasound Obstet Gynecol. 2003;21:338–341
  16. Hyett JA, Moscoso G, Nicolaides KH. Abnormalities of the heart and great arteries in first trimester chromosomally abnormal fetuses. Am J Med Genet. 1997;69:207–216
  17. Teitel D, Rudolph AM. Perinatal oxygen delivery and cardiac function. Adv Paediatr. 1985;32:321–347
  18. Rudolph AM, Heymann MA. Cardiac output in the fetal lamb: the effects of spontaneous and induced changes of heart rate on right and left ventricular output. Am J Obstet Gynecol. 1976;124:183–192

 Supported by the Fetal Medicine Foundation (Registered Charity 1037116).

PII: S0002-9378(05)01250-0

doi: 10.1016/j.ajog.2005.08.010

American Journal of Obstetrics & Gynecology
Volume 194, Issue 2 , Pages 397-401 , February 2006

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