American Journal of Obstetrics & Gynecology
Volume 193, Issue 3, Supplement , Pages 1121-1126 , September 2005

Fetal immune response to oral pathogens and risk of preterm birth

  • Kim A. Boggess, MD

      Affiliations

    • Department of Obstetrics and Gynecology, University of North Carolina School of Medicine
    • University of North Carolina School of Dentistry
    • Corresponding Author InformationReprints not available from the authors. Address correspondence to Kim A. Boggess, MD, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina School of Medicine, Campus Box 7516, Chapel Hill, NC 27599-7516.
    • ,
  • Kevin Moss

      Affiliations

    • Department of Dental Ecology, and Center for Oral and Systemic Diseases
    • University of North Carolina School of Dentistry
    • ,
  • Phoebus Madianos, PhD

      Affiliations

    • University of North Carolina School of Dentistry
    • ,
  • Amy P. Murtha, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Duke University Medical Center, Chapel Hill, NC
    • ,
  • James Beck, PhD

      Affiliations

    • Department of Dental Ecology, and Center for Oral and Systemic Diseases
    • University of North Carolina School of Dentistry
    • ,
  • Steven Offenbacher, DDS, PhD

      Affiliations

    • Department of Dental Ecology, and Center for Oral and Systemic Diseases
    • University of North Carolina School of Dentistry

Received 25 February 2005 ,Revised 9 May 2005 ,Accepted 10 May 2005.

References 

  1. Lieff S, Boggess KA, Murtha AP, Jared H, Madianos PN, Moss K, et al. The oral conditions and pregnancy study: periodontal status of a cohort of pregnant women. J Periodontol. 2004;75:116–126
  2. Moore S, Ide M, Coward PY, Randhawa M, Borkowska E, Baylis R, et al. A prospective study to investigate the relationship between periodontal disease and adverse pregnancy outcome. Br Dent J. 2004;197:251–258
  3. Boggess KA, Lieff S, Murtha AP, Moss K, Beck J, Offenbacher S. Maternal periodontal disease is associated with an increased risk for preeclampsia. Obstet Gynecol. 2003;101:227–231
  4. Offenbacher S, Katz V, Fertik G, Collins J, Boyd D, Maynor G, et al. Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol. 1996;67:1103–1113
  5. Dasanayake AP, Boyd D, Madianos PN, Offenbacher S, Hills E. The association between Porphyromonas gingivalis-specific maternal serum IgG and low birth weight. J Periodontol. 2001;72:1491–1497
  6. Jeffcoat MK, Geurs NC, Reddy MS, Cliver SP, Goldenerg RL, Hauth JC. Periodontal infection and preterm birth: results of a prospective study. J Am Dent Assoc. 2001;132:875–880
  7. Goepfert AR, Jeffcoat MK, Andrews WW, Faye-Petersen O, Cliver SP, Goldenberg RL, et al. Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol. 2004;104:777–783
  8. Madianos PN, Lieff S, Murtha AP, Boggess KA, Auten RL, Beck JD, et al. Maternal periodontitis and prematurity. II: Maternal infection and fetal exposure. Ann Periodontol. 2001;6:175–182
  9. Sakellari D, Socransky SS, Dibart S, Eftimiadi C, Taubman MA. Estimation of serum antibody to subgingival species using checkerboard immunoblotting. Oral Microbiol Immunol. 1997;12:303–310
  10. Maymon E, Ghezzi F, Edwin SS, Mazor M, Yoon BH, Gomez R, et al. The tumor necrosis factor alpha and its soluble receptor profile in term and preterm parturition. Am J Obstet Gynecol. 1999;181:1142–1148
  11. Yoon BH, Romero R, Shim JY, Shim SS, Kim CJ, Jun JK. C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. J Matern Fetal Neonatal Med. 2003;14:85–90
  12. Yoon BH, Romero R, Moon J, Chaiworapongsa T, Espinoza J, Kim YM, et al. Differences in the fetal interleukin-6 response to microbial invasion of the amniotic cavity between term and preterm gestation. J Matern Fetal Neonatal Med. 2003;13:32–38
  13. McGregor JA, French JI, Richter R, Franco-Buff A, Johnson A, Hillier S, et al. Antenatal microbiologic and maternal risk factors associated with prematurity. Am J Obstet Gynecol. 1990;163:1465–1473
  14. Schieve LA, Handler A, Hershow R, Persky V, Davis F. Urinary tract infection during pregnancy: its association with maternal morbidity and perinatal outcome. Am J Public Health. 1994;84:405–410
  15. Hillier SL, Nugent RP, Eschenbach DA, Krohn MA, Gibbs RS, Martin DH, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med. 1995;333:1737–1742
  16. Cotch MF, Pastorek JG, Nugent RP, Hillier SL, Gibbs RS, Martin DH, et al. Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group. Sex Transm Dis. 1997;24:353–360
  17. Conway SP, Dear PR, Smith I. Immunoglobulin profile of the preterm baby. Arch Dis Child. 1985;60:208–212
  18. Mahulja-Stamenkovic V, Beleznay O, Stamenkovic M, Samardzija R, Makis J. IgG, IgM and IgA umbilical blood concentrations in normal singleton vaginal deliveries with stinking amniotic fluid or intrapartal maternal febrility>or=38 degrees C or duration of delivery >12 hours. Zentralbl Gynakol. 1993;115:33–35

 Supported by K08 HD043284 (K. A. B.), R01 DE12453 (S. O.), and the University of North Carolina General Clinical Research Center grant RR00046.Presented at the Twenty-Fifth Annual Meeting of the Society for Maternal Fetal Medicine, February 7-12, 2005, Reno, Nev.

PII: S0002-9378(05)00729-5

doi: 10.1016/j.ajog.2005.05.050

American Journal of Obstetrics & Gynecology
Volume 193, Issue 3, Supplement , Pages 1121-1126 , September 2005

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