American Journal of Obstetrics & Gynecology
Volume 192, Issue 4 , Pages 1304-1313 , April 2005

Metabolites of progesterone and the pregnane X receptor: A novel pathway regulating uterine contractility in pregnancy?

  • Bryan F. Mitchell, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • Corresponding Author InformationReprint requests: Bryan F. Mitchell, Perinatal Research Centre, 220 HMRC, University of Alberta, Edmonton AB Canada T6G 2S2.
    • ,
  • Jana M. Mitchell, BSc

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • ,
  • Jeeshan Chowdhury

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • ,
  • Michelle Tougas, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • ,
  • Sanne M.E. Engelen, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • ,
  • Nancy Senff, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • ,
  • Iris Heijnen, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • ,
  • John T. Moore, PhD

      Affiliations

    • Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC
    • ,
  • Bryan Goodwin, MD, PhD

      Affiliations

    • Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC
    • ,
  • Susan Wong, MSc

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • ,
  • Sandra T. Davidge, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Perinatal Research Centre
    • Department of Physiology, University of Alberta, Edmonton, Alberta, Canada

Received 21 December 2004 ,Revised 21 December 2004 ,Accepted 19 January 2005.

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  35. Cooke CLM, Mitchell BF, S.G. Jagadeesh, Falck JR, Davidge ST. The progetserone metabolite 5β-DHT is a novel stimulator of epoxyeicosatrienoic acid (EET)-mediated relaxation: implications for vascular adaptation to pregnancy. [abstract] J Soc Gynecol Invest. 2003;10:330
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 Supported by grants from the Heart and Stroke Foundation of Canada, the Canadian Institutes of Health Research (Institute of Human Development, Child and Youth Health), and The Alberta Heritage Foundation for Medical Research.Presented at the 23rd Annual Meeting of the American Gynecological and Obstetrical Society, September 9-11, 2004, Bolton Landing, NY.

PII: S0002-9378(05)00117-1

doi: 10.1016/j.ajog.2005.01.040

American Journal of Obstetrics & Gynecology
Volume 192, Issue 4 , Pages 1304-1313 , April 2005

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