American Journal of Obstetrics & Gynecology
Volume 192, Issue 2 , Pages 452-457 , February 2005

Severe fetal placental vascular lesions in term infants with neurologic impairment

Received 19 May 2004 ,Revised 22 June 2004 ,Accepted 19 July 2004.

References 

  1. Freeman AD, Freeman JM. No-fault cerebral palsy insurance: an alternative to the obstetrical malpractice lottery. J Health Polit Policy Law. 1989;14:707–718
  2. Greenwood C, Newman S, Impey L, Johnson A. Cerebral palsy and clinical negligence litigation: a cohort study. BJOG. 2003;110:6–11
  3. MacLennan A. A template for defining a causal relation between acute intrapartum events and cerebral palsy: international consensus statement. BMJ. 1999;319:1054–1059
  4. Hagberg B, Hagberg G, Beckung E, Uvebrant P. Changing panorama of cerebral palsy in Sweden: VIII, prevalence and origin in the birth year period 1991-94. Acta Paediatr. 2001;90:271–277
  5. Cowan F, Rutherford M, Groenendaal F, Eken P, Mercuri E, Bydder GM, et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet. 2003;361:736–742
  6. Sander CH, Kinnane L, Stevens NG. Hemorrhagic endovasculitis of the placenta: a clinicopathologic entity associated with adverse pregnancy outcome. Compr Ther. 1985;11:66–74
  7. Naeye RL, Peters EC, Bartholomew MS, Landis RJ. Origins of cerebral palsy. Am J Dis Child. 1989;143:1154–1161
  8. Redline RW, O'Riordan MA. Placental lesions associated with cerebral palsy and neurologic impairment following term birth. Arch Pathol Lab Med. 2000;124:1785–1791
  9. Altshuler G, Arizawa M, Molnar-Nadasdy G. Meconium-induced umbilical cord vascular necrosis and ulceration: a potential link between the placenta and poor pregnancy outcome. Obstet Gynecol. 1992;79:760–766
  10. Redline RW, Pappin A. Fetal thrombotic vasculopathy: the clinical significance of extensive avascular villi. Hum Pathol. 1995;26:80–85
  11. Leviton A, Paneth N, Reuss ML, Susser M, Allred EN, Dammann O, et al. Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants: Developmental Epidemiology Network Investigators. Pediatr Res. 1999;46:566–575
  12. Langston C, Kaplan C, Macpherson T, Manci E, Peevy K, Clark B, et al. Practice guideline for examination of the placenta. Arch Pathol Lab Med. 1997;121:449–476
  13. Redline RW, Faye-Petersen O, Heller D, Qureshi F, Savell V, Vogler C. Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol. 2003;6:435–448
  14. Redline RW, Ariel I, Baergen RN, DeSa DJ, Kraus FT, Roberts DJ, et al. Fetal vascular obstructive lesions: nosology and reproducibility of placental reaction patterns. Pediat Dev Pathol [In Press].
  15. King EL, Redline RW, Smith SD, Kraus FT, Sadovsky Y, Nelson DM. Myocytes of chorionic vessels from placentas with meconium associated vascular necrosis exhibit apoptotic markers. Hum Pathol. 2004;35:412–417
  16. Dombrowski MP, Wolfe HM, Brans YW, Saleh AA, Sokol RJ. Neonatal morphometry: relation to obstetric, pediatric, and menstrual estimates of gestational age. Am J Dis Child. 1992;146:852–856
  17. Gaffney G, Flavell V, Johnson A, Squier M, Sellers S. Cerebral palsy and neonatal encephalopathy. Arch Dis Child. 1994;70:F195–F200
  18. Jarvis S, Glinianaia SV, Torrioli MG, Platt MJ, Miceli M, Jouk PS, et al. Cerebral palsy and intrauterine growth in single births: European collaborative study. Lancet. 2003;362:1106–1111
  19. Gruenwald P. Fetal deprivation and placental pathology: concepts and relationships. Perspect Pediatr Pathol. 1975;2:101–149
  20. Kraus FT, Acheen VI. Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol. 1999;30:759–769
  21. Leistra-Leistra MJ, Timmer A, van Spronsen FJ, Geven WB, van der Meer J, Erwich JJ. Fetal thrombotic vasculopathy in the placenta: A thrombophilic connection between pregnancy complications and neonatal thrombosis?. Placenta. 2004;25:S102–S105
  22. Dahms BB, Boyd T, Redline RW. Severe perinatal liver disease associated with fetal thrombotic vasculopathy. Pediatr Dev Pathol. 2002;5:80–85
  23. Redline RW, Shah D, Sakar H, Schluchter M, Salvator A. Placental lesions associated with abnormal growth in twins. Pediatr Dev Pathol. 2001;4:473–481
  24. Khong TY, Hague WM. Biparental contribution to fetal thrombophilia in discordant twin intrauterine growth restriction. Am J Obstet Gynecol. 2001;185:244–245
  25. Vern TZ, Alles AJ, KowalVern A, Longtine J, Roberts DJ. Frequency of factor V-Leiden and prothrombin G20210A in placentas and their relationship with placental lesions. Hum Pathol. 2000;31:1036–1043
  26. Mooney E, Vaughan J, Ryan F, Lafont A, McDonald WA, Kelehan P, et al. Placental thrombotic vasculopathy is not associated with thrombophilic mutations. [abstract] Lab Invest. 2003;83:303A
  27. Redline RW, Patterson P. Villitis of unknown etiology is associated with major infiltration of fetal tissue by maternal inflammatory cells. Am J Pathol. 1993;143:473–479
  28. Redline RW, Patterson P. Patterns of placental injury: correlations with gestational age, placental weight, and clinical diagnosis. Arch Pathol Lab Med. 1994;118:698–701
  29. Salafia C, Silberman L, Herrera N, Mahoney M. Placental pathology at term associated with elevated midtrimester serum alpha-fetoprotein concentration. Am J Obstet Gynecol. 1988;158:1064–1066
  30. Driscoll S. Autopsy following stillbirth: a challenge neglected. In:  Ryder O,  Byrd M editor. One medicine. Berlin: Springer-Verlag; 1984;
  31. Althabe O, Labarrere CA. Chronic villitis of unknown aetiology and intrauterine growth retardation infants of normal and low ponderal index. Placenta. 1985;6:369–373
  32. Scher MS, Trucco GS, Beggarly ME, Steppe DA, Macpherson TA. Neonates with electrically confirmed seizures and possible placental associations. Pediatr Neurol. 1998;19:37–41
  33. Artlett CM, Ramos R, Jiminez SA, Patterson K, Miller FW, Rider LG. Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies. Lancet. 2000;356:2155–2156
  34. Wu YW, Colford JM. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA. 2000;284:1417–1424
  35. Redline RW, Wilson-Costello D, Borawski E, Fanaroff AA, Hack M. Placental lesions associated with neurologic impairment and cerebral palsy in very low birth weight infants. Arch Pathol Lab Med. 1998;122:1091–1098
  36. Dammann O, Phillips TM, Allred EN, O'Shea TM, Paneth N, Van Marter LJ, et al. Mediators of fetal inflammation in extremely low gestational age newborns. Cytokine. 2001;13:234–239
  37. Katz VL, Bowes WA. Meconium aspiration syndrome: reflections on a murky subject. Am J Obstet Gynecol. 1992;166:171–183
  38. Kearney MS. Chronic intrauterine meconium aspiration causes fetal lung infarcts, lung rupture, and meconium embolism. Pediatr Dev Pathol. 1999;2:544–551
  39. Altshuler G, Hyde S. Meconium-induced vasocontraction: a potential cause of cerebral and other fetal hypoperfusion and of poor pregnancy outcome. J Child Neurol. 1989;4:137–142

 Reprints not available from the author.

PII: S0002-9378(04)00790-2

doi: 10.1016/j.ajog.2004.07.030

American Journal of Obstetrics & Gynecology
Volume 192, Issue 2 , Pages 452-457 , February 2005