American Journal of Obstetrics & Gynecology
Volume 191, Issue 1 , Pages 143-149 , July 2004

Translocation of lysophosphatidic acid phosphatase in response to gonadotropin-releasing hormone to the plasma membrane in ovarian cancer cell

Received 20 July 2003 ,Revised 31 December 2003 ,Accepted 21 January 2004.

References 

  1. Mills G, Eder A, Fang X, Hasegawa Y, Mao M, Lu Y, et al.  Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer. Cancer Treat Res. 2002;107:259–283
  2. Moolenaar W, Kranenburg O, Postma F, Zondag G. Lysophosphatidic acid: G-protein signalling and cellular responses. Curr Opin Cell Biol. 1997;9:168–173
  3. Westermann A, Beijnen J, Moolenaar W, Rodenhuis S. Growth factors in human ovarian cancer. Cancer Treat Rev. 1997;23:113–131
  4. Xu Y, Shen Z, Wiper D, Wu M, Morton R, Elson P, et al.  Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA. 1998;280:719–723
  5. Mills G, May C, McGill M, Roifman C, Mellors A. A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action. Cancer Res. 1988;48:1066–1071
  6. Mills G, May C, Hill M, Campbell S, Shaw P, Marks A. Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells. J Clin Invest. 1990;86:851–855
  7. Xu Y, Fang X, Casey G, Mills G. Lysophospholipids activate ovarian and breast cancer cells. Biochem J. 1995;309:933–940
  8. Xu Y, Gaudette D, Boynton J, Frankel A, Fang X, Sharma A, et al.  Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients. Clin Cancer Res. 1995;1:1223–1232
  9. Frankel A, Mills G. Peptide and lipid growth factors decrease cis-Diamminedichloplatinum-induced cell death in human cancer cells. Clin Cancer Res. 1996;2:1307–1313
  10. Fukushima N, Ishii I, Contos J, Weiner J, Chun J. Lysophospholipid receptors. Annu Rev Pharmacol Toxicol. 2001;41:507–534
  11. Hla T, Lee M, Ancellin N, Paik J, Kluk M. Lysophospholipids-receptor revelations. Science. 2001;294:1875–1878
  12. Brindley D, Waggoner D. Mammalian lipid phosphate phosphohydrolases. J Biol Chem. 1998;273:24281–24284
  13. Roberts R, Sciorra V, Morris A. Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. J Biol Chem. 1998;273:22059–22067
  14. Roberts R, Morris A. Role of phosphatidic acid phosphatase 2a in uptake of extracellular lipid phosphate mediators. Biochim Biophys Acta. 2000;1487:33–49
  15. Imai A, Furui T, Tamaya T, Mills G. A gonadotropin-releasing hormone-responsive phosphatase hydrolyses lysophosphatidic acid within the plasma membrane of ovarian cancer cells. J Clin Endocrinol Metab. 2000;85:3370–3375
  16. Imai A, Horibe S, Takagi H, Fuseya T, Tamaya T. Signal transduction of GnRH receptor in the reproductive tract tumor. Endocr J. 1996;43:249–260
  17. Emons G, Orthmann O, Schulz K, Schally A. Growth-inhibitory actions of analogues of luteinizing hormone releasing hormone on tumor cells. Trends Endocrinol Metab. 1997;8:355–362
  18. Imai A, Tamaya T. GnRH receptor and apoptotic signaling. Vitam Horm. 2000;59:1–33
  19. Imai A, Ohno T, Iida K, Fuseya T, Furui T, Tamaya T. Gonadotropin-releasing hormone receptor in gynecologic tumors: frequent expression in adenocarcinoma histologic types. Cancer. 1994;74:2555–2561
  20. Imai A, Takagi A, Horibe S, Takagi H, Tamaya T. Evidence for tight coupling of gonadotropin-releasing hormone receptor to stimulated Fas ligand expression in reproductive tract tumors: possible mechanism for hormonal control of apoptotic cell death. J Clin Endocrinol Metab. 1998;83:427–431
  21. Imai A, Gershengorn MC. Measurement of lipid turnover in response to TRH. Methods Enzymol. 1987;141:100–111
  22. Imai A, Gershengorn MC. Independent phosphatidylinositol synthesis in rat pituitary plasma membrane and endoplasmic reticulum. Nature. 1987;325:725–728
  23. Lowry OH, Rosenbrough N, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275
  24. Kai M, Wada I, Imai S, Sakane F, Kanoh H. Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase. J Biol Chem. 1997;272:24572–24578
  25. Sciorra V, Morris A. Sequential actions of phospholipase D and phosphatidic acid phosphorylase 2b generate diglyceride in mammalian cells. Mol Biol Cell. 1999;10:3863–3876
  26. Hsu S, Raine L, Fanger H. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol. 1981;75:816–821
  27. Shi S, Key M, Kalra K. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem. 1991;39:741–748
  28. Schmidt A, Wolde M, Thiele C, Fest W, Kratzin H, Podtelejnikov A, et al.  Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature. 1999;401:133–141
  29. Barila D, Plateroti M, Nobili F, Muda A, Xie Y, Morimoto T, et al.  The Dri 42 gene, whose expression is up-regulated during epithelial differentiation, encodes a novel endoplasmic reticulum resident transmembrane protein. J Biol Chem. 1996;271:29928–29936
  30. Jasinska R, Zhang Q, Pilquil C, Singh I, Xu J, Dewald J, et al.  Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters. Biochem J. 1999;340:677–686

 Supported in part by research grants (#12470340 and #14770844) from the Ministry of Education, Culture and Science, Japan.

PII: S0002-9378(04)00085-7

doi: 10.1016/j.ajog.2004.01.038

American Journal of Obstetrics & Gynecology
Volume 191, Issue 1 , Pages 143-149 , July 2004