American Journal of Obstetrics & Gynecology
Volume 186, Issue 5, Supplement , Pages S81-S93 , May 2002

Epidural analgesia side effects, co-interventions, and care of women during childbirth: A systematic review

References 

  1. Campbell DC, Banner R, Crone L, Gore-Hickman W, Yip RW. Addition of epinephrine to intrathecal bupivacaine and sufentanil for ambulatory labor analgesia. Anesthesiology. 1997;86:525–531
  2. Campbell D, Zwack R, Crone L, Yip R. Ambulatory labor epidural analgesia: bupivacaine versus ropivacaine. Anesth Analg. 2000;90:1384–1389
  3. Breen T, Shapiro T, Glass B, Foster-Payne D, Oriol N. Epidural anesthesia for labor in an ambulatory patient. Anesth Analg. 1993;77:919–924
  4. Sia AT, Ching JL, Tay DH, Lo WK, Chen LH, Chiu JW. Intrathecal sufentanil as the sole agent in combined spinal-epidural analgesia for the ambulatory parturient. Can J Anaesthesia. 1998;45:620–625
  5. Meister G, D'Angelo R, Owen M, Nelson K, Gaver R. A comparison of epidural analgesia with 0.125% ropivacaine with fentanyl versus 0.125% bupivacaine with fentanyl during labor. Anesth Analg. 2000;90:632–637
  6. Olofsson C, Ekblom A, Ekman-Ordeberg G, Irestedt I. Obstetric outcome following epidural analgesia with bupivacaine-adrenaline 0.25% or bupivacaine 0.125% with sufentanil-;a prospective randomized trial. Acta Anaesthesiol Scand. 1998;42:284–292
  7. Asokumar B, Newman LM, McCarthy RJ, Ivankovitch AD, Tuman KJ. Intrathecal bupivacaine reduces pruritus and prolongs duration of fentanyl analgesia during labor: a prospective randomized controlled trail. Anesth Analg. 1998;87:1309–1315
  8. Claes B, Soetens M, Van-Zundert A, Datta S. Clonidine added to bupivacaine-epinephrine-sufentanil improves analgesia during childbirth. Reg Anesth Pain Med. 1998;23:540–547
  9. Nageotte MP, Larson D, Rumney PJ, Sidhu M, Hollenbach K. Epidural analgesia with combined spinal-epidural analgesia during labor in nulliparous women. New Engl J Med. 1997;337:1715–1719
  10. Connelly N, Parker R, Vallurupulli V, Bhopatkar S, Dunn S. Comparison of epidural fentanyl versus epidural sufentanil for analgesia in ambulatory patients in early labor. Anesth Analg. 2000;91:374–378
  11. Celleno D, Capogna G, Costantino P, Zangrillo A. Comparison of fentanyl with clonidine as adjuncts for epidural analgesia with 0.125% bupivacaine in the first stage of labor: a preliminary report. Int J Obstet Anesth. 1995;4:26–29
  12. Levin A, Datta S, Camman WR. Intrathecal ropivacaine for labor analgesia: a comparison with bupivacaine. Anesth Analg. 1998;87:634–727
  13. Dahl V, Koss K, Nordentoft J, Raedert J. Bupivacaine 2.5 mg/ml versus bupivacaine 0.625 mg/ml and sufentanil 1 μg/ml with or without epinephrine 1 μg/ml for epidural analgesia in labour. Int J Obstet Anesth. 1999;8:155–160
  14. Cascio M, Pygon B, Bernett C, Ramanathan S. Labour analgesia with intrathecal fentanyl decreases maternal stress. Can J Anaesth. 1997;44:605–609
  15. Herman NLO, Choi KC, Affleck PJ, Calicott R, Brackin R, Singhal A, et al.  Analgesia, pruritus, and ventilation exhibit a dose-response relationship in parturients receiving intrathecal fentanyl during labor. Anesth Analg. 1999;89:378–383
  16. Mardirosoff C, Dumont L. Two doses of intrathecal sufentanil (2.5 + 5 μg) combined with bupivacaine and epinephrine for labor analgesia. Anesth Analg. 1999;89:1263–1266
  17. Gautier PE, Debry F, Fanard L, Van-Steerberg A, Hody JL. Ambulatory combined spinal-epidural analgesia for labor: influence of epinephrine on bupivacaine-sufentanil combination. Reg Anesth. 1997;22:143–149
  18. Dounas M, O'Kelly B, Jamali S, Mercier FJ, Benhamou D. Maternal and fetal effects of adrenaline with bupivacaine (0.25%) for epidural analgesia during labour. Eur J Anaesthesiol. 1996;13:594–598
  19. Sia A, Chong J, Chiu J. Combination of intrathecal sufentanil 120 μg plus bupivacaine 2.5 mg for labor analgesia: is half the dose enough?. Anesth Analg. 1999;88:362–366
  20. Tan TK. Epidural analgesia in obstetrics. Ann Acad Med Singapore. 1999;27:235–242
  21. Bromage PR. Epidural analgesia. In: Philadelphia: WB Saunders; 1978;p. 513–600
  22. Kendrick W, Woods A, Daly M, Birch R, Cosmo D. Naloxone versus nalbuphine infusion for morphine-induced pruritus. Anesth Analg. 1995;82:641–647
  23. Carbonne B, Benachi A, Leveque ML, Cabrol D, Papiernik E. Maternal position during labor: effects on fetal oxygen saturation measured by pulse oxymetry. Obstet Gynecol. 1996;88:797–800
  24. Hofmeyr G. Prophylactic intravenous preloading for regional analgesia in labour (Cochrane Review) 2000. The Cochrane Library. Oxford: Update Software; 2000; Issue 3
  25. Cheek T, Samuels P, Miller F, Tobin M, Gutsche B. Normal saline I.V. fluid load decreased uterine activity in active labour. Brit J Anaesth. 1996;77:632–635
  26. Panzer O, Ghazanfari N, Sessier D, Yukse Y, Greher M, et al.  Shivering and shivering-like tremor during labor with and without epidural analgesia. Anesthesiology. 1999;90:1609–1616
  27. Lieberman E, Cohen A, Lang J, Frigoletto F, Goetzl L. Maternal intrapartum temperature elevation as a risk factor for cesarean delivery and assisted vaginal delivery. Am J Public Health. 1999;89:506–510
  28. Collis RE, Davies DWL, Aveling W. Randomized comparison of combined spinal-epidural and standard epidural analgesia in labor. Lancet. 1995;54:535–539
  29. Albright GA, Forster RM. The safety and efficacy of combined spinal and epidural analgesia/anesthesia (6002 blocks) in a community hospital. Reg Anesth Pain Med. 1999;24:117–125
  30. Gambling D, Sharma S, Ramin SM, Lucas MJ, Leveno KJ, Wiley J, et al.  A randomized study of combined spinal-epidural analgesia versus intravenous meperidine during labor: impact on cesarean delivery rate. Anesthesiology. 1998;89:1336–1344
  31. Sharma S, Sidawi J, Ramin S, Lucas M, Leveno K, Cunningham FG. Cesearean delivery: a randomized trial of epidural versus patient-controlled meperidine analgesia during labor. Anesthesiology. 1997;87:487–494
  32. Ramin S, Gambling DR, Lucas MJ, Sharma SK, Sidawi JE, Leveno KJ. Randomized trial of epidural versus intravenous analgesia during labor. Obstet Gynecol. 1995;86:783–789
  33. Clark A, Carr D, Loyd G, Cook V, Spinnato J. The influence of epidural analgesia on cesarean delivery rates: a randomized, prospective clinical trial. Am J Obstet Gynecol. 1998;179:1527–1533
  34. Thorp JA, Hu DH, Albin RM, McNitt J, Meyer BA, Cohen GR, et al.  The effect of intrapartum epidural analgesia on nulliparous labor: a randomized, controlled prospective trial. Am J Obstet Gynecol. 1993;169:851–858
  35. Bofill JA, Vincent RD, Ross EL, Martin RW, Norman PF, Werhan CF, et al.  Nulliparous active labor, epidural analgesia, and cesarean delivery for dystocia. Am J Obstet Gynecol. 1997;177:1465–1470
  36. Guidozzi F, Graham KM, Buchmann EJ, Christophers GJ. The effect of continuous low-dose epidural analgesia on uterine work during the active phase of the first stage of labour. South Afr Med J. 1992;81:361–362
  37. Newton ER, Schroeder BC, Knape KG, Bennett BL. Epidural analgesia and uterine function. Obstet Gynecol. 1995;85:749–755
  38. Petersen L, Besuner P. Pushing techniques during labor: issues and controversies. JOGNN. 1997;26:719–726
  39. Aldrich CJ, D'Antona D, Spencer JD, Wyatt JS, Peebles DM, Delpy DT, et al.  The effect of maternal pushing on fetal cerebral oxygenation and blood volume during the second stage of labour. Br J Obstet Gynaecol. 1995;102:448–453
  40. Mayberry LJ, Gennaro S, Strange L, Williams M, De A. Maternal fatigue: implications of second stage labor nursing care. JOGNN. 1999;28:175–181
  41. Sampselle C, Hines S. Spontaneous pushing during birth. J Nurse Midwifery. 1999;44:36–39
  42. Vause S, Congdon HM, Thornton JG. Immediate and delayed pushing in the second stage of labour for nulliparous women with epidural analgesia: a randomized controlled trial. Br J Obstet Gynaecol. 1998;105:186–188
  43. Mayberry LJ, Hammer R, Kelly C, True-Driver B, De A. Use of delayed pushing with epidural anesthesia: findings from a randomized, controlled trial. J Perinatol. 1999;19:26–30
  44. Fraser WD, Marcoux S, Krauss I, Douglas C, Boulvain M. Multicenter, randomized, controlled trial of delayed pushing for nulliparous women in the second stage of labor with continuous epidural analgesia. The PEOPLE (Pushing Early or Pushing Late with Epidural) Study Group. Am J Obstet Gynecol. 2000;182:1165–1172
  45. Gupta JK, Nikoderm VC. Woman's position during second stage of labour (Cochrane Review) 2000. The Cochrane Library. Oxford: Update Software; 2000; Issue 3
  46. Gilder K, Mayberry LJ, Gennaro S, Clemmens D. Maternal positioning in labor with epidural analgesia: results from a multisite survey. Lifelines. 2002;6: (accepted)
  47. Hodnett ED. Caregiver support for women during childbirth (Cochrane Review). The Cochrane Library. Oxford: Update Software; 2002; issue 1
  48. Gagnon AJ, Waghorn K. Supportive care by maternity nurses: a work sampling study in an intrapartum unit. Birth. 1996;23:1–6
  49. McNiven P, Hodnett E, O'sBrien-Pallas LL. Supporting women in labor: a work sampling of the activities of labor and delivery nurses. Birth. 1992;19:3–9
  50. Gale J, Fothergill-Bourbonnais F, Chamberlain M. Measuring nursing support during childbirth. MCN Am J Matern Child Nurs. 2001;26:264–271
  51. Scott DB, Tunstall ME. Serious complications associated with epidural/spinal blockade in obstetrics: a two-year prospective study. Int J Obstet. 1995;4:133–139

 Reprint requests: Linda J. Mayberry, 135 Davenport Farm Lane, West Stamford, CT 06903. ljm6@is9.nyu.edu

PII: S0002-9378(02)70184-1

American Journal of Obstetrics & Gynecology
Volume 186, Issue 5, Supplement , Pages S81-S93 , May 2002