Human papillomavirus–associated cervical cytologic abnormalities among women with or at risk of infection with human immunodeficiency virus☆☆☆

Abstract 

Objective: Correlates of abnormal human immunodeficiency virus cervical cytologic findings were examined among women infected with human immunodeficiency virus and uninfected women. Study Design: We performed a cross-sectional analysis of baseline data on demographically similar women with infection or risk factors for it. Results: Among 1050 women without hysterectomy, squamous intraepithelial lesions were more common among women infected with human immunodeficiency virus than among uninfected women (18.8% vs 5.3%; P < .001). In multivariate analysis the association of squamous intraepithelial lesions with human papillomavirus infection was strong; adjusted prevalence ratios were 27 for high-risk, 25 for intermediate-risk, and 10 for low-risk types (95% confidence intervals, 12-58, 12-54, and 4-25, respectively). Much lower adjusted prevalence ratios were seen for the only other factor significantly associated with squamous intraepithelial lesions, namely, infection with human immunodeficiency virus in conjunction with a reduced CD4⁺ cell count. Adjusted prevalence ratios were 1.9 for CD4⁺ cell counts <200 and 1.6 for CD4⁺ cell counts between 200 and 500 (95% confidence intervals, 1.2-3.0 and 1.0-2.5, respectively). Adjusted attributable fractions calculated for this study population indicated that if both human immunodeficiency virus and human papillomavirus were removed, 47.6% of the observed lesions with atypical squamous cells of uncertain significance and 93.4% of the observed squamous intraepithelial lesions would be prevented. Conclusion: Squamous intraepithelial lesions are more common among human immunodeficiency virus–infected women and are associated most commonly with high- and intermediate-risk human papillomavirus types and secondarily with human immunodeficiency virus–associated immune compromise. (Am J Obstet Gynecol 2001;184:584-90.)

Keywords:  Cervical cytologic abnormalities, human immunodeficiency virus, human papillomavirus