American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 605.e1-605.e8, December 2009

Tea consumption and risk of endometrial cancer: a metaanalysis

  • Na-Ping Tang, MD

      Affiliations

    • Corresponding Author InformationReprints: Jing Ma, PhD, or Na-Ping Tang, MD, National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, 199 Guoshoujing Rd., Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, China
    • ,
  • Hua Li, MD
    • ,
  • Yun-Liang Qiu, MD
    • ,
  • Guo-Min Zhou, PhD
    • ,
  • Jing Ma, PhD

      Affiliations

    • Corresponding Author InformationReprints: Jing Ma, PhD, or Na-Ping Tang, MD, National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, 199 Guoshoujing Rd., Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, China

National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai Institute of Pharmaceutical Industry, Pudong, Shanghai, China

Received 26 February 2009; received in revised form 12 May 2009; accepted 14 July 2009. published online 23 September 2009.

Objective

The objective of the study was to assess the association between tea consumption and endometrial cancer.

Study Design

Studies were identified by searching PubMed and EMBASE databases and screening the references of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated.

Results

The combined RR for ever drinkers vs non/lowest drinkers was 0.85 (95% CI, 0.77–0.94). Compared with non/lowest drinkers, the summary RR was 0.88 (95% CI, 0.78–0.98) for low to moderate drinkers and 0.75 (95% CI, 0.64–0.88) for high drinkers. An increase in tea intake of 2 cups/day was associated with a 25% decreased risk of endometrial cancer. In subgroup analyses, tea consumption was significantly associated with reduced endometrial cancer risk in Asian studies and studies using interviewing techniques. Furthermore, the protective effect of green tea on endometrial cancer seemed more evident than that of black tea.

Conclusion

Findings from this metaanalysis suggest that tea consumption may reduce the risk of endometrial cancer. Because of the limited number of studies, further prospective studies are needed to explore the protective effect of tea on endometrial cancer.

Key words: endometrial cancer, metaanalysis, tea consumption

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 This article was supported by Grants from the Major Projects Foundation of the National Science and Technology of China (no. 2008ZX09305-006) and the National Natural Science Foundation of China (no. 90709036).

 Cite this article as: Tang N-P, Li H, Qiu Y-L, et al. Tea consumption and risk of endometrial cancer: a metaanalysis. Am J Obstet Gynecol 2009;201:605.e1-8.

PII: S0002-9378(09)00817-5

doi:10.1016/j.ajog.2009.07.030

American Journal of Obstetrics & Gynecology
Volume 201, Issue 6 , Pages 605.e1-605.e8, December 2009

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