Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes
Presented as a poster at the 29th Annual Meeting of the Society for Maternal-Fetal Medicine, San Diego, CA, Jan. 28-31, 2009.
Received 26 February 2009; received in revised form 1 June 2009; accepted 30 June 2009.
Objective
We sought to demonstrate that elevated first-trimester uric acid is associated with development of gestational diabetes mellitus (GDM).
Study Design
Uric acid was measured in 1570 plasma samples collected at mean gestational age of 8.9 ± 2.5 weeks. The primary outcome was GDM, diagnosed by 3-hour glucose tolerance test using Carpenter and Coustan criteria or by a 1-hour value of ≥200 mg/dL. Logistic regression was performed, adjusting for relevant covariates.
Results
Almost half (46.6%) of the women with GDM had first-trimester uric acid concentrations in the highest quartile (>3.57-8.30 mg/dL). Women with uric acid in the highest quartile had a 3.25-fold increased risk (95% confidence interval, 1.35–7.83) of developing GDM after adjustment for body mass index and age. This effect was concentration dependent as risk increased with increasing uric acid quartiles (P = .003).
Conclusion
First-trimester hyperuricemia is associated with an increased risk of developing GDM, independent of body mass index.
aDepartment of Obstetrics, Gynecology and Reproductive Services, University of Pittsburgh School of Medicine, Pittsburgh, PA
bDepartment of Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
cDepartment of Environmental and Occupational Health, University of Pittsburgh School of Medicine, Pittsburgh, PA
dMagee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA
Reprints: S. Katherine Laughon, MD, MS, NICHD/National Institutes of Health, Division of Epidemiology, Statistics and Prevention Research, Building 6100, Room 7B03, Bethesda, MD 20892
Funding was provided by Grant NIH P01 HD030367 for the Pregnancy Exposures and Preeclampsia Prevention Study and by the University of Pittsburgh Clinical and Translational Science Award UL1 RR024153 for Magee-Womens Hospital Clinical and Translational Research Center.
Cite this article as: Laughon SK, Catov J, Provins T, et al. Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes. Am J Obstet Gynecol 2009;201:402.e1-5.
ABSTRACT