Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies
Received 20 June 2008; received in revised form 23 September 2008; accepted 7 October 2008. published online 29 December 2008.
We conducted a metaanalysis of published studies on the relation between coffee drinking and endometrial cancer risk, which included 2 cohort (201 cases) and 7 case-control studies (2409 cases). The summary relative risk (RR) for coffee drinkers vs nondrinkers was 0.80 (95% confidence interval [CI], 0.68-0.94), with significant heterogeneity between studies. Compared with nondrinkers, the summary RR was 0.87 (95% CI, 0.78-0.97) for low-to-moderate coffee drinkers and 0.64 (95% CI, 0.48-0.86) for heavy coffee drinkers. The summary RR for an increase of 1 cup/d was 0.93 (95% CI, 0.89-0.97), which suggests an inverse relation between coffee and endometrial cancer. However, the causality must be confirmed.
aIstituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
bIstituto di Statistica Medica e Biometria “G.A. Maccacaro”, Università degli Studi di Milano, Milan, Italy
cDipartimento di Statistica, Università di Milano Bicocca, Italy
Reprints: Francesca Bravi, ScD, Istituto di Ricerche Farmacologiche “Mario Negri,” Dipartimento di Epidemiologia, Via Giuseppe La Masa 19-20156 Milan MI, Italy
This work was conducted with the contribution of the Italian Association for Cancer Research, and the Italian League Against Cancer. The work of this paper was undertaken while CLV was a Senior Fellow at the International Agency for Research on Cancer (IARC).
Authorship and contribution to the manuscript is limited to the 7 authors indicated. There was no outside funding or technical assistance with the production of this article.
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