American Journal of Obstetrics & Gynecology
Volume 202, Issue 6 , Pages 550.e1-550.e10, June 2010

A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia

Presented at the 56th Annual Scientific Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland, United Kingdom, March 17-21, 2009.

  • Tinnakorn Chaiworapongsa, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • Corresponding Author InformationReprints: Tinnakorn Chaiworapongsa, MD, Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Wayne State University/Hutzel Women's Hospital, 3990 John R, Box 4, Detroit, MI 48201
    • ,
  • Roberto Romero, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
    • ,
  • Adi L. Tarca, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Computer Science, Wayne State University, Detroit, MI
    • ,
  • Juan Pedro Kusanovic, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Francesca Gotsch, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • ,
  • Pooja Mittal, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Sun Kwon Kim, MD, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Pathology, Wayne State University, Detroit, MI
    • ,
  • Edi Vaisbuch, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Shali Mazaki-Tovi, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Offer Erez, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Zhong Dong, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • ,
  • Chong Jai Kim, MD, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Pathology, Wayne State University, Detroit, MI
    • ,
  • Lami Yeo, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Sonia S. Hassan, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI and Bethesda, MD
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI

Received 14 April 2009; received in revised form 27 May 2009; accepted 5 April 2010.

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 This research was supported, in part, by the Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services.

 Cite this article as: Chaiworapongsa T, Romero R, Tarca AL, et al. A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia. Am J Obstet Gynecol 2010;202:550.e1-10.

PII: S0002-9378(10)00415-1

doi:10.1016/j.ajog.2010.04.002

American Journal of Obstetrics & Gynecology
Volume 202, Issue 6 , Pages 550.e1-550.e10, June 2010

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