American Journal of Obstetrics & Gynecology
Volume 201, Issue 3 , Pages 281.e1-281.e9 , September 2009

A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome

Presented at the 29th Annual Meeting of the Society for Maternal-Fetal Medicine, San Diego, CA, Jan. 26-31, 2009.

  • James Cox, PhD

      Affiliations

    • Metabolomics Core Research Facility, University of Utah Health Sciences, Salt Lake City, UT
  • ,
  • Sarah Williams, MSc

      Affiliations

    • Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR
  • ,
  • Kevin Grove, PhD

      Affiliations

    • Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR
  • ,
  • Robert H. Lane, MD

      Affiliations

    • Division of Neonatology, Department of Pediatrics, University of Utah Health Sciences, Salt Lake City, UT
  • ,
  • Kjersti M. Aagaard-Tillery, MD, PhD

      Affiliations

    • Division of Neonatology, Department of Pediatrics, University of Utah Health Sciences, Salt Lake City, UT
    • Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX

Received 21 February 2009 ,Revised 22 April 2009 ,Accepted 16 June 2009.

References 

  1. Strauss RS, Pollack HA. Epidemic increase in childhood overweight, 1986-1998. JAMA. 2001;286:2845–2848
  2. Kopelman PG. Obesity as a medical problem. Nature. 2000;404:635–643
  3. Field A, Coakley EH, Must A, et al. Impact of overweight on the risk of developing common chronic diseases during a 10 year period. Arch Intern Med. 2001;161:1581–1586
  4. Finkelstein EA, Ruhm CJ, Kosa KM. Economic causes and consequences of obesity. Annu Rev Public Health. 2005;26:239–257
  5. Rennie KL, Jebb SA. Prevalence of obesity in Great Britain. Obes Rev. 2005;6:11–20
  6. Popkin BM, Gordon-Larsen P. The nutrition transition: worldwide obesity dynamics and their determinants. Int J Obesity. 2004;28:S2–S9
  7. Grove KL, Grayson BE, Glavas MM, Xiao XQ, Smith MS. Development of metabolic systems. Physiol Behav. 2005;86:646–660
  8. Bhargava SK, Sachdev HS, Fall CH, et al. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N Engl J Med. 2004;350:865–875
  9. Speiser PW, Rudolf MC, Anhalt H, et al. Obesity Consensus Working Group Childhood obesity. J Clin Endocrinol Metab. 2005;90:871–887
  10. Barker DJ. Fetal origins of coronary heart disease. BMJ. 1995;311:171–174
  11. Eriksson JG, Forsen T, Tuomilheto J, Osmond C, Barker DJP. Early growth and coronary heart disease in later life: longitudinal study. BMJ. 2001;322:949–953
  12. Klebanoff MA, Meirik O, Berendes HW. Second-generation consequences of small-for-dates birth. Pediatrics. 1989;84:243–247
  13. Gluckman PD, Lillycrop KA, Vickers MH, et al. Metabolic plasticity during mammalian development is directionally dependent on early nutritional status. Proc Natl Acad Sci U S A. 2007;104:12796–12800
  14. Burdge GC, Slater-Jefferies J, Torrens C, Phillips ES, Hanson MA, Lillicrop KA. Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr. 2007;97:435–439
  15. Lillycrop KA, Slater-Jefferies JL, Hanson MA, Godfrey KM, Jackson AA, Burdge GC. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferace-1 expression is involved in impaired DNA methylation changes in histone modifications. Br J Nutr. 2007;97:1064–1073
  16. MacLennan NK, James SJ, Melnyk S, et al. Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics. 2004;18:43–50
  17. Fu Q, McKnight RA, Yu X, Callaway CW, Lane RH. Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5. FASEB. 2006;20:2127–2129
  18. Fu Q, McKnight RA, Yu X, Wang L, Callaway CW, Lane RH. Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning day 0 IUGR rat liver. Physiol Genomics. 2004;20:108–116
  19. McCurdy CE, Bishop JM, Williams SM, Smith MS, Friedman JE, Grove KL. Chronic maternal high fat diet triggers fetal hepatic reprogramming and fatty liver in the nonhuman primate. J Clin Invest. 2009;119:323–335
  20. Aagaard-Tillery KM, Grove K, Bishop J, et al. Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome. J Mol Endocrinol. 2008;41:91–102
  21. Loftus N, Miseki K, Iida J, Gika HG, Theodoridis G, Wilson ID. Profiling and biomarker identification in serum from different Zucker rat strains via high mass accuracy multistage mass spectrometric analysis using liquid chromatography/mass spectrometry with a quadrupole ion trap-time of flight mass spectrometer. Rapid Commun Mass Spectrom. 2008;22:2547–2554
  22. Werner E, Heiler J-F, Ducruiz C, Ezan E, Junot C, Tabet J-C. Mass spectrometry for the identification of the discriminating signals from metabolomics: current status and future trends. J Chromat. 2008;871:143–163
  23. Trygg AJ, Gullberg J, Johansson A, et al. Extraction and GC/MS analysis of the human blood serum metabolome. Anal Cham. 2005;77:8086–8094
  24. Briegelieus-Flohe R, Traber MG. Vitamin E: function and metabolism. FASEB. 1999;13:1145–1155
  25. Azzi A, Aratri E, Boscoboinik D, et al. Molecular basis of alpha-tocopherol control of smooth muscle cell proliferation. Biofactors. 2008;7:3–14
  26. Bonet B, Viana M, Sánchez-Vera I, Quintanar A, Martínez J, Espino M. Adipose tissue and liver lipid metabolism in obese children: role of the body mass index and the presence of acanthosis nigricans. Diabet Med. 2007;24:1192–1198
  27. Bugianesi E, Gastaldelli A, Vanni E, et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia. 2005;48:634–642
  28. Palinski W, Napoli C. The fetal origins of atherosclerosis: maternal hypercholesterolemia, and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and postnatal susceptibility to atherogenesis. FASEB. 2002;16:1348–1360

 Reprints not available from the authors.

 Support for this work was provided by the National Institutes of Health (NIH) Director New Innovator Pioneer Award DP21DP2OD001500-01 (K.A.T.), and NIH Grants 1R01DK080558 (R.H.L. and K.A.T.), DK60685-0351 (K.L.G.), 1R01DK079194 (K.L.G.), and RR00163 (K.L.G.-ONPRC).

 Cite this article as: Cox J, Williams S, Grove K, et al. A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome. Am J Obstet Gynecol 2009;201:281.e1-9.

PII: S0002-9378(09)00685-1

doi: 10.1016/j.ajog.2009.06.041

American Journal of Obstetrics & Gynecology
Volume 201, Issue 3 , Pages 281.e1-281.e9 , September 2009