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American Journal of Obstetrics & Gynecology
Volume 200, Issue 4
, Pages 392.e1-392.e10
, April 2009
Circulating angiogenic factors in gestational proteinuria without hypertension
References
- . Latest advances in understanding preeclampsia. Science. 2005;308:1592–1594
- Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006;12:642–649
- Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med. 2006;355:992–1005
- Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia. J Matern Fetal Neonatal Med. 2005;17:3–18
- Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J Clin Endocrinol Metab. 2003;88:2348–2351
- Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672–683
- Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649–658
- . Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia. Obstet Gynecol. 2003;101:1266–1274
- Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest. 2003;111:707–716
- Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice. J Am Soc Nephrol. 2002;13:1548–1560
- . Neutralizing TGF-beta1 antibody infusion in neonatal rat delays in vivo glomerular capillary formation 1. Kidney Int. 1999;56:1334–1348
- . Glomerular endothelial cells are maintained by vascular endothelial growth factor in the adult kidney. Tohoku J Exp Med. 2001;195:43–54
- Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem. 2003;278:12605–12608
- Impaired angiogenesis in the remnant kidney model: I, potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol. 2001;12:1434–1447
- Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia. Hypertension. 2007;50:686–692
- Protective effect of vascular endothelial growth factor/vascular permeability factor 165 and 121 on glomerular endothelial cell injury in the rat. Lab Invest. 2004;84:1126–1136
- VEGF(165) mediates glomerular endothelial repair. J Clin Invest. 1999;104:913–923
- Vascular endothelial growth factor165 resolves glomerular inflammation and accelerates glomerular capillary repair in rat anti-glomerular basement membrane glomerulonephritis. J Am Soc Nephrol. 2004;15:2655–2665
- A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 2003;349:427–434
- . Natural history of chronic proteinuria complicating pregnancy. Am J Obstet Gynecol. 1992;167:1219–1224
- Trial of calcium to prevent preeclampsia. N Engl J Med. 1997;337:69–76
- Trial of Calcium for Preeclampsia Prevention (CPEP): rationale, design, and methods. Control Clin Trials. 1996;17:442–469
- . Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330:565
- . Serum sFlt1 concentration during preeclampsia and mid trimester blood pressure in healthy nulliparous women. Am J Obstet Gynecol. 2006;194:1034–1041
- Risk factors for preeclampsia in healthy nulliparous women: a prospective multicenter study: the National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine units. Am J Obstet Gynecol. 1995;172:642–648
- . Is pre-eclampsia more than one disease?. BJOG. 2004;111:298–302
- . Relationship between urinary albumin and serum soluble fms-like tyrosine kinase 1 (sFlt-1) in normal pregnancy. Eur J Obstet Gynecol Reprod Biol. 2006;128:204–208
- Glomerular endotheliosis in normal pregnancy and pre-eclampsia. BJOG. 2003;110:831–836
- . Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis. Am J Obstet Gynecol. 2006;194:551–556
- . Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies. Am J Obstet Gynecol. 2003;188:177–182
- A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med. 2008;21:9–23
- . Chronic renal disease in pregnancy. Obstet Gynecol. 2006;108:1531–1539
This study was supported by funds and salary from the intramural research program of the National Institutes of Health and by salary from the US Navy; by the National Institute of Child Health and Human Development under contracts N01-HD-1-3121 through 3126, N01-HD-3154, and N01-HD-5-3246, with cofunding from the National Heart, Lung, and Blood Institute (Calcium for Preeclampsia Prevention trial database and specimen repository); and by National Institutes of Health Grants DK065997 and HL079594 (S.A.K., an investigator of the Howard Hughes Medical Institute).
The views expressed are those of the authors and do not reflect the official policy or position of the Department of Defense or the US Government.
Dr Karumanchi reports having served as a consultant to Abbott, Beckman Coulter, Roche, and Johnson & Johnson and having been named co-inventor on multiple provisional patents that were filed by Beth Israel Deaconess Medical Center for the use of angiogenesis-related proteins for the diagnosis and treatment of preeclampsia. These patents have been nonexclusively licensed to several companies.
Cite this article as: Holston AM, Qian C, Yu KF, Epstein FH, Karumanchi SA, Levine RJ. Circulating angiogenic factors in gestational proteinuria without hypertension. Am J Obstet Gynecol 2009;200:392.e1-392.e10.
PII: S0002-9378(08)02045-0
doi: 10.1016/j.ajog.2008.10.033
© 2009 Mosby, Inc. All rights reserved.
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American Journal of Obstetrics & Gynecology
Volume 200, Issue 4
, Pages 392.e1-392.e10
, April 2009
