American Journal of Obstetrics & Gynecology
Volume 200, Issue 1 , Pages 46.e1-46.e5 , January 2009

Maternal thrombophilia and the risk of recurrence of preeclampsia

  • Fabio Facchinetti, MD

      Affiliations

    • Mother-Infant Department, Unit of Gynecology and Obstetrics, Faculty of Medicine and Surgery, University of Modena and Reggio Emilia, Italy
    • Corresponding Author InformationReprints: Professor Fabio Facchinetti, Dipartimento Materno Infantile, Via del Pozzo 71, 41100 Modena, Italy
    • ,
  • Luca Marozio, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine and Surgery, University of Turin, Turin, Italy
    • ,
  • Tiziana Frusca, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, University of Brescia, Brescia, Italy
    • ,
  • Elvira Grandone, MD

      Affiliations

    • Atherosclerosis and Thrombosis Unit, Istituto di Ricovero e Cura a Carettere Scientifico “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo (FG), Italy
    • ,
  • Paolo Venturini, MD

      Affiliations

    • Mother-Infant Department, Unit of Gynecology and Obstetrics, Faculty of Medicine and Surgery, University of Modena and Reggio Emilia, Italy
    • ,
  • Giovanni Luca Tiscia, MD

      Affiliations

    • Atherosclerosis and Thrombosis Unit, Istituto di Ricovero e Cura a Carettere Scientifico “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo (FG), Italy
    • ,
  • Sonia Zatti, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine, University of Brescia, Brescia, Italy
    • ,
  • Chiara Benedetto, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Faculty of Medicine and Surgery, University of Turin, Turin, Italy

Received 9 January 2008 ,Revised 29 April 2008 ,Accepted 15 July 2008.

References 

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  2. Lin J, August P. Genetic thrombophilia and preeclampsia: a meta-analysis. Obstet Gynecol. 2005;105:182–192
  3. Mello G, Parretti E, Marozio L, et al. Thrombophilia is significantly associated with severe preeclampsia (Results of a large-scale, case-controlled study). Hypertension. 2005;46:1270–1274
  4. Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330:565–568
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  8. Parazzini F, Cortinovis I, Bortolus R, Fedele L, Recarli A. Weight at birth by gestational age in Italy. Hum Reprod. 1995;10:1862–1863
  9. Sibai BM, El-Nazer A, Gonzalez-Ruiz A. Severe preeclampsia-eclampsia in young primigravid women: subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol. 1986;155:1011–1016
  10. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet. 1995;346:1133–1134
  11. Sibai BM, Lindheimer M, Hauth J, et al. Risk factors for preeclampsia, abruptio placentae, and adverse neonatal outcomes among women with chronic hypertension. N Engl J Med. 1998;339:667–671
  12. Knight M, Duley L, Henderson-Smart DJ, King JF. Antiplatelet agents for preventing and treating preeclampsia. Cochrane Database Syst Rev. 2002;2:CD000492
  13. Gris JC, Lissalde-Lavigne G, Qhéré I, Dauzat M, Marés P. Prophylaxis and treatment of thrombophilia in pregnancy. Curr Opin Hematol. 2006;13:376–381
  14. van Walraven C, Mamdani M, Cohn A, Katib Y, Walker M, Rodger MA. Risk of subsequent thromboembolism for patients with pre-eclampsia. BMJ. 2003;326:791–792
  15. Wilson BJ, Watson MS, Prescott GJ, et al. Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study. BMJ. 2003;326:845–849
  16. Pabinger I, Grafenhofer H, Kaider A, et al. Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis. J Thromb Haemost. 2005;3:949–954

 Cite this article as: Facchinetti F, Marozio L, Frusca T, et al. Maternal thrombophilia and the risk of recurrence of preeclampsia. Am J Obstet Gynecol 2009;200:46.e1-46.e5.

PII: S0002-9378(08)00815-6

doi: 10.1016/j.ajog.2008.07.032

American Journal of Obstetrics & Gynecology
Volume 200, Issue 1 , Pages 46.e1-46.e5 , January 2009

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