American Journal of Obstetrics & Gynecology
Volume 199, Issue 2 , Pages 122.e1-122.e11 , August 2008

First-trimester maternal serum PP13 in the risk assessment for preeclampsia

Presented at the 27th Annual Meeting of the Society for Maternal-Fetal Medicine, San Francisco, CA, Feb. 5-10, 2007.

  • Roberto Romero, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI
    • Corresponding Author InformationReprints: Roberto Romero, MD, Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Wayne State University/Hutzel Women's Hospital, 3990 John R, Box 4, Detroit, MI 48201.
    • ,
  • Juan Pedro Kusanovic, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Nandor Gabor Than, MD, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
    • ,
  • Offer Erez, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • ,
  • Francesca Gotsch, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • ,
  • Jimmy Espinoza, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Samuel Edwin, PhD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • ,
  • Ilana Chefetz, MSc

      Affiliations

    • Diagnostic Technologies, Yokneam, Israel
    • ,
  • Ricardo Gomez, MD

      Affiliations

    • Center for Perinatal Diagnosis and Research, Sótero del Río Hospital, P. Universidad Católica de Chile, Puente Alto, Chile
    • ,
  • Jyh Kae Nien, MD

      Affiliations

    • Center for Perinatal Diagnosis and Research, Sótero del Río Hospital, P. Universidad Católica de Chile, Puente Alto, Chile
    • ,
  • Marei Sammar, PhD

      Affiliations

    • Diagnostic Technologies, Yokneam, Israel
    • ,
  • Beth Pineles, BS

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • ,
  • Sonia S. Hassan, MD

      Affiliations

    • Perinatology Research Branch, National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD, and Detroit, MI
    • Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI
    • ,
  • Hamutal Meiri, PhD

      Affiliations

    • Diagnostic Technologies, Yokneam, Israel
    • ,
  • Yossi Tal, PhD

      Affiliations

    • TechnoSTAT, Kfar Sabah, Israel
    • ,
  • Ido Kuhnreich, MSc

      Affiliations

    • TechnoSTAT, Kfar Sabah, Israel
    • ,
  • Zoltan Papp, MD, DSci

      Affiliations

    • First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
    • ,
  • Howard S. Cuckle, PhD

      Affiliations

    • Leeds Screening Centre, University of Leeds, Leeds, UK
    • Department of Obstetrics and Gynecology, Columbia University, New York, NY.

Received 9 July 2007 ,Revised 17 October 2007 ,Accepted 11 January 2008.

  • Image Result

    PP13 MoMs according to the study groups

    The results are based on the first model in which PP13 MoM was adjusted to GA and BMI. The boxplot represents the medians (as a horizontal line within the box),

    PP13 MoMs according to the study groups

    The results are based on the first model in which PP13 MoM was adjusted to GA and BMI. The boxplot represents the medians (as a horizontal line within the box), the 25th and 75th quartiles, and the maximum and minimum for each group. Red dots refer to outliers in the right position, and the filled red dot refers to a clipped outlier outside the range of the figure. PE, preeclampsia.

    Romero. First-trimester PP13 and preterm preeclampsia. Am J Obstet Gynecol 2008.

  • Image Result
    ROC curve depicting the sensitivity and specificity of PP13 MoM in maternal serum for the identification of all cases of preeclampsiaThe results are based on the second model in which PP13 MoM was adj

    ROC curve depicting the sensitivity and specificity of PP13 MoM in maternal serum for the identification of all cases of preeclampsia

    The results are based on the second model in which PP13 MoM was adjusted to GA, BMI, maternal age, and parity.

    Romero. First-trimester PP13 and preterm preeclampsia. Am J Obstet Gynecol 2008.

  • Image Result
    ROC curves depicting the sensitivity and specificity of first trimester maternal serum PP13 MoM for the identification of the different clinical subtypes of preeclampsiaA, ROC curves were generated ba

    ROC curves depicting the sensitivity and specificity of first trimester maternal serum PP13 MoM for the identification of the different clinical subtypes of preeclampsia

    A, ROC curves were generated based on the first model in which PP13 MoM was adjusted to GA and BMI. PE, preeclampsia. The diagnostic indices that were generated from these curves are presented in Table 4A. B, ROC curves were generated based on the second model in which PP13 MoM was adjusted to GA, BMI, maternal age, and parity. PE, preeclampsia. The diagnostic indices that were generated from these curves are presented in Table 4B.

    Romero. First-trimester PP13 and preterm preeclampsia. Am J Obstet Gynecol 2008.

 Cite this article as: Romero R, Kusanovic JP, Than NG, et al. First-trimester maternal serum PP13 in the risk assessment for preeclampsia. Am J Obstet Gynecol 2008;199:122.e1-122.e11.

 This research was supported, in part, by the Intramural Research Program of the National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institutes of Health, Department of Health and Human Services, and Grants 31851 and 42872 from Israel Chief Scientist (to H.M.).

PII: S0002-9378(08)00028-8

doi: 10.1016/j.ajog.2008.01.013

American Journal of Obstetrics & Gynecology
Volume 199, Issue 2 , Pages 122.e1-122.e11 , August 2008

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