American Journal of Obstetrics & Gynecology
Volume 198, Issue 4 , Pages 357-366 , April 2008

Fibroids and reproductive outcomes: a systematic literature review from conception to delivery

  • Peter C. Klatsky, MD

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine New York, NY
  • ,
  • Nam D. Tran, MD, PhD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA.
  • ,
  • Aaron B. Caughey, MD, PhD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA.
  • ,
  • Victor Y. Fujimoto, MD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA.

Received 19 July 2007 ,Revised 29 November 2007 ,Accepted 31 December 2007.

References 

  1. Practice Committee of the ASRM. Myomas and reproductive function. Fertil Steril. 2004;82:S111–S116
  2. Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA, et al. Variation in the incidence of uterine leiomyoma among premenapausal women by age and race. Obstet Gynecol. 1997;90:967–973
  3. Chen CR, Buck GM, Courey NG, Perez KM, Wactawski-Wende J. Risk factors for uterine fibroids among women undergoing tubal sterilization. Am J Epidemiol. 2001;153:27–29
  4. Qidway IG, Caughey AB, Jacoby AF. Obstetric outcomes in women with sonographically identified uterine leiomyomas. Obstet Gynecol. 2006;107:376–382
  5. Ramzy AM, Sattar M, Amin Y, Mansour RT, Serour GI, Aboulghar MA. Uterine myomata and outcome of assisted reproduction. Hum Reprod. 1998;13:198–202
  6. Klatsky PC, Lane DR, Ryan I, Fujimoto VY. The effect of intramural and subserosal fibroids on ART outcomes independent of ovarian age. Hum Reprod. 2007;22:521–526
  7. Farhi J, Ashkenazi J, Feldberg D, Dicker D, Orvieto R, Ben Rafael Z. The effects of uterine leiomyomata on in-vitro fertilization treatment. Hum Reprod. 1995;10:2576–2578
  8. Rosenfeld DL. Abdominal myomectomy for otherwise unexplained infertility. Fertil Steril. 1986;46:328–330
  9. Elder-Geva T, Meagher S, Healy DL, Maclachlan V, Breheny S, Wood C. Effect of intramural, subserosal, and submucosal uterine fibroids on the outcome of assisted reproductive technology treatment. Fertil Steril. 1998;70:687–691
  10. Pritts EA. Fibroids and Infertility: a systematic review. Obstet Gynecol Surv. 2001;56:483–491
  11. Shokeir TA. Hysteroscopic management in submucous fibroids to improve fertility. Arch Gynecol Obstet. 2005;273:50–54
  12. Narayan R, Rajat , Goswamy K. Treatment of submucous fibroids, and outcome of assisted conception. ? J Am Assoc Gynecol Laparosc. 1994;1:307–311
  13. Surrey ES, Minjarez DA, Stevens JM, Schoolcraft WB. Effect of myomectomy on the outcome of assisted reproductive technologies. Fertil Steril. 2005;83:1473–1479
  14. Casini ML, Rossi F, Agostini R, Unfer V. Effects of the position of fibroids on fertility. Gynecol Endocrinol. 2006;22:106–109
  15. Stovall DW, Parrish SB, Van Voorhis BJ, Hahn SJ, Sparks AET, Syrop CH. Uterine leiomyomas reduce the efficacy of assisted reproduction cycles. Hum Reprod. 1998;13:192–197
  16. Hart R, Khalaf Y, Yeong CT, Seed P, Taylor A, Braude P. A prospective controlled study of the effect of intramural uterine fibroids on the outcome of assisted conception. Hum Reprod. 2001;16:2411–2417
  17. Surrey ES, Lietz AK, Schoolcraft WB. Impact of intramural leiomyomata in patients with a normal endometrial cavity on in vitro fertilization-embryo. Fertil Steril. 2001;75:405–410
  18. Jun SH, Ginsurg ES, Racowsky C, Wise LA, Hornstein MD. Uterine leiomyomas and their effect on in vitro fertilization outcome. J Assist Reprod Genet. 2001;18:139–143
  19. Yarali H, Bukulmez O. The effect of intramural and subserous uterine fibroids on implantation and clinical pregnancy rates in patients having intracytoplasmic sperm injection. Arch Gynecol Obstet. 2002;266:30–33
  20. Check JH, Choe JK, Lee G, Dietterich C. The effect on IVF outcome of small intramural fibroids not compressing the uterine cavity as determined by a prospective matched control study. Hum Reprod. 2002;17:1244–1248
  21. Wang W, Check JH. Effect of corporal fibroids on outcome following embryo transfer in donor embryo recipients. Clin Exp Obstet Gynecol. 2004;31:263–264
  22. Oliveira FG, Abdelmassih VG, Diamond MP, Dozortsey D, Melo NR, Abdelmassih R. Impact of subserosal and intramural fibroids that do not distort the endometrial cavity on the outcome of in vitro fertilization-intracytoplasmic sperm injection. Fertil Steril. 2004;81:582–587
  23. Buletti C, De Ziegler D, Polli V, Flamigni C. The role of leiomyomas in infertility. J Am Assoc Gynecol Laparosc. 1999;6:441–445
  24. Benson CB, Chow JS, Chang-Lee W, Hill JA, Doubilet PM. Outcome of pregnancies in women with uterine leiomyomas identified by sonography in the first trimester. J Clin Ultrasound. 2001;29:261–264
  25. Gianaroli L, Gordts S, D’Angelo A, Magli MC, Brosens I, Cetera C, et al. Effect of inner myometrium fibroid on reproductive outcome after IVF. Reprod Biomed Online. 2005;10:473–477
  26. Khalaf Y, Ross C, El-Toukhy T, Hart R, Seed P, Braude P. The effect of small intramural uterine fibroids on the cumulative outcome of assisted conception. Hum Reprod. 2006;21:2640–2644
  27. Feinberg EC, Larsen FW, Catherino WH, Zhang J, Armstrong AY. Comparison of assisted reproductive technology utilization and outcome between Caucasian and African American patients in an equal-access-to-care setting. Fertil Steril. 2006;85:888–894
  28. Buttram VC, Reiter RC. Uterine leiomyomata: etiology, symptomology, and management. Fertil Steril. 1981;36:433–445
  29. Li TC, Motimer R, Cooke ID. Myomectomy: a retrospective study to examine performance before and after surgery. Hum Reprod. 1999;14:1735–1740
  30. Benson CB, Chow JS, Chang-Lee W, Hill JA, Doubilet PM. Outcome of pregnancies in women with uterine leiomyomas identified by sonography in the first trimester. J Clin Ultrasound. 2001;29:261–264
  31. Exacoustos C, Rosati P. Ultrasound diagnosis of uterine myomas and complications in pregnancy. Obstet Gynecol. 1993;82:97–101
  32. Katz VL, Dotters DJ, Droegemueller W. Complications of uterine leiomyomas in pregnancy. Obstet Gynecol. 1989;73:593–596
  33. Norton M, Merril J, Cooper BA, Kuller JA, Clyman RI. Neonatal complications after administration of indomethecin for preterm labor. N Engl J Med. 1993;329:1602–1607
  34. Neiger R, Sonek JD, Croom CS, Ventolini G. Pregnancy related changes in the size of uterine leiomyomas. J Reprod Med. 2006;51:671–674
  35. Aharoni A, Reiter A, Golan D, Paltiey Y, Scharff M. Patterns of growth of uterine leiomyomas during pregnancy: a prospective longitudinal study. BJOG. 1988;95:510–513
  36. Lev-Toaff AS, Coleman BJ, Arger PH, Mintz MZ, Arenson RL, Toaff ME. Leiomyomas in pregnancy: a sonographic study. Radiology. 1987;164:375–380
  37. Muram D, Gillieson M, Walters JH. Myomas of the uterus in pregnancy: ultrasonographic follow-up. Am J Obstet Gynecol. 1980;138:16–19
  38. Rice JP, Kay HH, Mahoney BS. The clinical significance of uterine leiomyomas in pregnancy. Am J Obstet Gynecol. 1989;160:1212–1216
  39. Qidwai IG, Caughey AB, Jacoby AF. Obstetric outcomes in women with sonographically identified uterine leiomyomata. Obstet Gynecol. 2006;107:376–382
  40. Coronado GD, Marshall LM, Schwartz SM. Complications in pregnancy, labor, and delivery with uterine leiomyomas: a population-based study. Obstet Gynecol. 2000;95:764–769
  41. Vergani P, Ghidini A, Strobelt N, Roncaglia N, Locatelli A, Lapinski RH, et al. Do uterine leiomyomas influence pregnancy outcome?. Am J Perinatol. 1994;11:356–358
  42. Vergani P, Locatelli A, Ghidini A, Andreani M, Sala F, Pezullo JC. Large uterine leiomyomata and risk of cesarean delivery. Obstet Gynecol. 2007;109:410–414
  43. Davis JL, Ray-Mazumder S, Hobel CJ, Baley K, Sassoon D. Uterine leiomyomas in pregnancy: a prospective study. Obstet Gynecol. 1990;75:41–44
  44. Sheiner E, Bashiri A, Levy A, Hershkovitz R, Katz M, Mazor M. Obstetric characteristics and perinatal outcome of pregnancies with uterine leiomyomas. J Reprod Med. 2004;49:182–186
  45. Roberts WE, Fulp KS, Morrison JC, Martin JN. The impact of leiomyomas on pregnancy. Aus N Z J Obstet Gynaecol. 1999;39:43–47
  46. American College of Gynecology. Committee Opinion Number 293. Washington, DC: The College; 2004;
  47. Walker WJ, McDowell SJ. Pregnancy after uterine artery embolization for lyomyomata: a series of 56 completed pregnancies. Am J Obstet Gynecol. 2006;195:1266–1271
  48. Pron G, Mocarski E, Bennett J, Vilos G, Common A, Vanderburgh L. Pregnancy after uterine artery embolization for leiomyomata: the Ontario multicenter trial. Obstet Gynecol. 2005;105:67–76
  49. Goldberg J, Pereira L, Berghella V, Diamond J, Daraï E, Seinera P, et al. Pregnancy outcomes after treatment for fibromyomata: uterine artery embolization versus laparoscopic myomectomy. Am J Obstet Gynecol. 2004;191:18–21
  50. Dickersin K, Min YI. Publication bias: the problem that won’t go away. Ann NY Acad Sci. 1993;703:135–146
  51. Decullier E, Lheritier V, Chapuis F. Fate of biomedical research protocols and publication bias in France: retrospective cohort study. BMJ. 2005;331;:191–196

 Reprints not available from authors.

PII: S0002-9378(08)00006-9

doi: 10.1016/j.ajog.2007.12.039

American Journal of Obstetrics & Gynecology
Volume 198, Issue 4 , Pages 357-366 , April 2008