American Journal of Obstetrics & Gynecology
Volume 198, Issue 3 , Pages 268.e1-268.e6 , March 2008

Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife—SWAN, the study of women’s health across the nation

Presented at the 17th Annual Meeting of the North American Menopause Society, Nashville, TN, Oct. 11-14, 2006.

  • Kavitha T. Ram, MD, MS

      Affiliations

    • Department of Obstetrics and Gynecology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY
    • Department of Obstetrics-Gynecology, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Paul Bobby, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Susan M. Hailpern, DrPH, MS

      Affiliations

    • Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY
    • ,
  • Joan C. Lo, MD

      Affiliations

    • Division of Research, Kaiser Permanente Northern California, Oakland, CA
    • ,
  • Miriam Schocken, PhD, MPH

      Affiliations

    • Division of Geriatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA
    • ,
  • Joan Skurnick, PhD

      Affiliations

    • Department of Preventive Medicine and Community Health, New Jersey Medical School–University of Medicine and Dentistry of New Jersey, Newark, NJ.
    • ,
  • Nanette Santoro, MD

      Affiliations

    • Department of Obstetrics-Gynecology, Albert Einstein College of Medicine, Bronx, NY
    • Corresponding Author InformationReprints: Nanette Santoro, MD, Director, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Mazer Bldg, Room 316, Bronx, NY 10461.

Received 6 June 2007 ,Revised 14 September 2007 ,Accepted 21 November 2007.

References 

  1. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes. 1992;41:715–722
  2. Kip KE, Marroquin OC, Kelley DE, et al. Clinical Importance of obesity versus MetSyn in cardiovascular risk in women: a report from the Women’s Ischemia Syndrome Evaluation (WISE) study. Circulation. 2004;109:706–713
  3. Trevisan M, Liu J, Bahsas FB, Menotti A. Syndrome X and mortality: a population- based study. Risk Factor and Life Expectancy Research Group. Am J Epidemiol. 1998;148:958–966
  4. Brewer MM, Bates MR, Vannoy LP. Postpartum changes in maternal weight and body fat depots in lactating vs. nonlactating women. Am J Clin Nutr. 1989;49:259–265
  5. Sichieri R, Field AE, Rich-Edwards J, Willett WC. Prospective assessment of exclusive breastfeeding in relation to weight change in women. Int J Obes Relat Metab Disord. 2003;27:815–820
  6. Kjos SL, Henry O, Lee RM, Buchanan TA, Mishell DR. The effect of lactation on glucose and lipid metabolism in women with recent gestational DM. Obstet Gynecol. 1993;82:451–455
  7. Qureshi IA, Xi XR, Limbu YR, Bin HY, Chen MI. Hyperlipidemia during normal pregnancy, parturition, and lactation. Ann Acad Med. 1999;28:217–221
  8. McManus RM, Cuingham I, Watson A, Harker L, Finegood DT. Beta-cell function and visceral fat in lactating women with a history of gestational DM. Metabolism. 2001;50:715–719
  9. Butte NF, Hopkinson JM, Mehta N, Moon JK, Smith EO. Adjustments in energy expenditure and substrate utilization during late pregnancy and lactation. Am J Clin Nutr. 1999;69:299–307
  10. Illingworth PJ, Jung RT, Howie PW, Leslie P, Isles TE. Diminution in energy expenditure during lactation. Br Med J. 1986;292:437–441
  11. Stuebe AM, Rich-Edwards JW, Willett WC, Manson JE, Michels KB. Duration of lactation and incidence of type 2 DM. JAMA. 2005;294:2601–2610
  12. Lee SY, Kim MT, Jee SH, Yang HP. Does long-term lactation protect premenopausal women against HTN risk? (A Korean Women’s cohort study). Prev Med. 2005;41:433–438
  13. Sowers MF, Crawford SL, Sternfeld B. SWAN: A multicenter, multiethnic, community-based cohort study of women and the menopausal transition. In:  Lobo RA,  Kelsey J,  Marcus R editor. Menopause: biology and pathobiology. San Diego, CA: Academic Press; 2000;p. 175–188
  14. Block G, Hartman AM, Dresser CM, Carroll MD, Gannon J, Gardner L. A data-based approach to diet questionnaire design and testing. Am J Epidemiol. 1986;124:453–469
  15. Sternfeld B, Ainsworth BA, Quesenberry CP. Physical activity patterns in a diverse population of women. Prev Med. 1999;28:313–323
  16. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143–3421
  17. Cohen A, Pieper CF, Brown AJ, Bastian LA. Number of children and risk of metabolic syndrome in women. J Womens Health. 2006;15:763–773
  18. Gunderson EP, Lewis CE, Wei GS, Whitmer RA, Quesenberry CP, Sidney S. Lactation and changes in maternal metabolic risk factors. Obstet Gynecol. 2007;109:729–738
  19. Rassmussen KM, Hilson JA, Kjolhede CL. Obesity may impair lactogenesis II. J Nutr. 2001;131:3009S–3011S
  20. Donath SM, Amir LH. Does maternal obesity adversely affect breastfeeding initiation and duration?. J Pediatr Child Health. 2000;36:482–486
  21. Hilson JA, Rasmussen KM, Kjolhede CL. Maternal obesity and breast- feeding success in a rural population of white women. [correction appears in Am J Clin Nutr 1998;67:494] Am J Clin Nutr. 1997;66:1371–1378
  22. Kark JD, Troya G, Friedlander Y, Slater PE, Stein Y. Validity of maternal reporting of breast feeding and the association with blood lipids in 17 year olds in Jerusalem. J Epidemiol Commun Health. 1984;38:218–225
  23. Recall by mothers of the birth weights and feeding of their children. Human Nutr Appl Nutr. 1986;40:171–175
  24. VanDam RM, Willet WC, Manson JE, Hu FB. The relationship between overweight in adolescence and premature death in women. Ann Intern Med. 2006;145:91–97
  25. Camastra S, Bonora E, Del Prato S, Rett K, Weck M, Ferrannini E. Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man. Int J Obes. 1999;23:1307–1313

 The Study of Women’s Health Across the Nation (SWAN) has grant support from the National Institutes of Health, Department of Health and Human Services, through the National Institute on Aging, the National Institute of Nursing Research, and the National Institutes of Health Office of Research on Women’s Health (Grants NR004061, AG012505, AG012535, AG012531, AG012539, AG012546, AG012553, AG012554, and AG012495).

 Cite this article as: Ram KT, Bobby P, Hailpern SM, et al. Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife—SWAN, the study of women’s health across the nation. Am J Obstet Gynecol 2008;198:268.e1-268.e6.

PII: S0002-9378(07)02226-0

doi: 10.1016/j.ajog.2007.11.044

American Journal of Obstetrics & Gynecology
Volume 198, Issue 3 , Pages 268.e1-268.e6 , March 2008

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