American Journal of Obstetrics & Gynecology
Volume 197, Issue 4 , Pages 416.e1-416.e5 , October 2007

Characterization of a murine model of fetal programming of atherosclerosis

Presented at the 27th Annual Clinical Meeting of the Society for Maternal–Fetal Medicine, San Francisco, CA, Feb. 5-10, 2007.

Received 12 March 2007 ,Revised 8 May 2007 ,Accepted 2 August 2007.

References 

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  2. Barker DJ. In utero programming of cardiovascular disease. Theriogenology. 2000;53:555–574
  3. Napoli C, D’Armiento FP, Mancini FP, et al. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia (Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions). J Clin Invest. 1997;100:2680–2690
  4. Napoli C, Glass CK, Witztum JL, Deutsch R, D’Armiento FP, Palinski W. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet. 1999;354:1234–1241
  5. Palinski W, D’Armiento FP, Witztum JL, et al. Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits. Circ Res. 2001;89:991–996
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  7. Jawien J, Nastalek P, Korbut R. Mouse models of experimental atherosclerosis. J Physiol Pharmacol. 2004;55:503–517
  8. Wouters K, Shiri-Sverdlov R, van Gorp PJ, van Bilsen M, Hofker MH. Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice. Clin Chem Lab Med. 2005;43:470–479
  9. Nunnari JJ, Zand T, Joris I, Majno G. Quantitation of oil red O staining of the aorta in hypercholesterolemic rats. Exp Mol Pathol. 1989;51:1–8
  10. Yoshida S, Wada Y. Transfer of maternal cholesterol to embryo and fetus in pregnant mice. J Lipid Res. 2005;46:2168–2174
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 Reprints not available from the authors.

 Supported in part by the Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX.

 Cite this article as: Goharkhay N, Sbrana E, Gamble PK, et al. Characterization of a murine model of fetal programming of atherosclerosis. Am J Obstet Gynecol 2007;197:416.e1-416.e5.

PII: S0002-9378(07)00968-4

doi: 10.1016/j.ajog.2007.08.002

American Journal of Obstetrics & Gynecology
Volume 197, Issue 4 , Pages 416.e1-416.e5 , October 2007

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