American Journal of Obstetrics & Gynecology
Volume 193, Issue 6 , Pages 1999-2003 , December 2005

Cervical anti-inflammatory cytokine concentrations among first-trimester pregnant smokers

  • Hyagriv N. Simhan, MD, MSCR

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine
    • Division of Reproductive Infectious Diseases and Immunology, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA
    • ,
  • Steve N. Caritis, MD

      Affiliations

    • Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine
    • ,
  • Sharon L. Hillier, PhD

      Affiliations

    • Division of Reproductive Infectious Diseases and Immunology, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA
    • ,
  • Marijane A. Krohn, PhD

      Affiliations

    • Division of Reproductive Infectious Diseases and Immunology, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA

Received 4 February 2005 ,Revised 1 April 2005 ,Accepted 25 April 2005.

References 

  1. Verkerk PH, Zaadstra BM, Reerink JD, Herngreen WP, Verloove-Vanhorick SP. Social class, ethnicity and other risk factors for small for gestational age and preterm delivery in The Netherlands. Eur J Obstet Gynecol Reprod Biol. 1994;53:129–134
  2. Moore ML, Zaccaro DJ. Cigarette smoking, low birth weight, and preterm births in low-income African American women. J Perinatol. 2000;20:176–180
  3. Hadley CB, Main DM, Gabbe SG. Risk factors for preterm premature rupture of the fetal membranes. Am J Perinatol. 1990;7:374–379
  4. Goldenberg RL, Das A. Fetal fibronectin and bacterial vaginosis in smokers and nonsmokers: the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol. 2000;182:164–166
  5. Creasy RK, Gummer BA, Liggins GC. System for predicting spontaneous preterm birth. Obstet Gynecol. 1980;55:692–695
  6. Romero R, Mazor M, Munoz H, Gomez R, Galasso M, Sherer DM. The preterm labor syndrome. Ann NY Acad Sci. 1994;734:414–429
  7. Narahara H, Johnston JM. Smoking and preterm labor: effect of a cigarette smoke extract on the secretion of platelet-activating factor-acetylhydrolase by human decidual macrophages. Am J Obstet Gynecol. 1993;169:1321–1326
  8. Simhan HN, Caritis SN, Krohn MA, Martinez de Tejada B, Landers DV, Hillier SL. Decreased cervical proinflammatory cytokines permit subsequent upper genital tract infection during pregnancy. Am J Obstet Gynecol. 2003;189:560–567
  9. Genc MR, Witkin SS, Delaney ML, Paraskevas LR, Tuomala RE, Norwitz ER, et al. A disproportionate increase in IL-1beta over IL-1ra in the cervicovaginal secretions of pregnant women with altered vaginal microflora correlates with preterm birth. Am J Obstet Gynecol. 2004;190:1191–1197
  10. Arntzen KJ, Kjollesdal AM, Halgunset J, Vatten L, Austgulen R. TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor. J Perinatal Med. 1998;26:17–26
  11. Szczepanik AM, Funes S, Petko W, Ringheim GE. IL-4, IL-10 and IL-13 modulate A beta(1-42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. J Neuroimmunol. 2001;113:49–62
  12. Wang P, Wu P, Anthes JC, Siegel MI, Egan RW, Billah MM. Interleukin-10 inhibits interleukin-8 production in human neutrophils. Blood. 1994;83:2678–2683
  13. Ruetten H, Thiemermann C. Interleukin-13 is a more potent inhibitor of the expression of inducible nitric oxide synthase in smooth muscle cells than in macrophages: a comparison with interleukin-4 and interleukin-10. Shock. 1997;8:409–414
  14. Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu D, et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA. 1992;89:1890–1893
  15. Muchamuel T, Menon S, Pisacane P, Howard MC, Cockayne DA. IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production. J Immunol. 1997;158:2898–2903
  16. Mijatovic T, Kruys V, Caput D, Defrance P, Huez G. Interleukin-4 and -13 inhibit tumor necrosis factor-alpha mRNA translational activation in lipopolysaccharide-induced mouse macrophages. J Biol Chem. 1997;272:14394–14398
  17. Lugering N, Kucharzik T, Stein H, Winde G, Lugering A, Hasilik A, et al. IL-10 synergizes with IL-4 and IL-13 in inhibiting lysosomal enzyme secretion by human monocytes and lamina propria mononuclear cells from patients with inflammatory bowel disease. Dig Dis Sci. 1998;43:706–714
  18. Lindmark E, Tenno T, Chen J, Siegbahn A. IL-10 inhibits LPS-induced human monocyte tissue factor expression in whole blood. Br J Haematol. 1998;102:597–604
  19. Kambayashi T, Jacob CO, Strassmann G. IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulated murine peritoneal mononuclear phagocytes. Cellular Immunol. 1996;171:153–158
  20. Kuga S, Otsuka T, Niiro H, Nunoi H, Nemoto Y, Nakano T, et al. Suppression of superoxide anion production by interleukin-10 is accompanied by a downregulation of the genes for subunit proteins of NADPH oxidase. Exp Hematol. 1996;24:151–157
  21. Goodwin VJ, Sato TA, Mitchell MD, Keelan JA. Anti-inflammatory effects of interleukin-4, interleukin-10, and transforming growth factor-beta on human placental cells in vitro. Am J Reprod Immunol (Copenhagen). 1998;40:319–325
  22. Gilmour JS, Hansen WR, Miller HC, Keelan JA, Sato TA, Mitchell MD. Effects of interleukin-4 on the expression and activity of prostaglandin endoperoxide H synthase-2 in amnion-derived WISH cells. J Molec Endocrinol. 1998;21:317–325
  23. Burguet A, Kaminski M, Abraham-Lerat L, Schaal JP, Cambonie G, Fresson J, et al. The complex relationship between smoking in pregnancy and very preterm delivery: results of the Epipage study. BJOG. 2004;111:258–265
  24. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol. 1991;29:297–301
  25. Simhan HN, Chura JC, Rauk PN. The effect of the anti-inflammatory cytokines interleukin-4 and interleukin-10 on lipopolysaccharide-stimulated production of prostaglandin E(2) by cultured human decidual cells. J Reprod Immunol. 2004;64:1–7
  26. Lain KY, Powers RW, Krohn MA, Ness RB, Crombleholme WR, Roberts JM. Urinary cotinine concentration confirms the reduced risk of preeclampsia with tobacco exposure. Am J Obstet Gynecol. 1999;181:1192–1196
  27. Haddow JE, Knight GJ, Palomaki GE, Kloza EM, Wald NJ. Cigarette consumption and serum cotinine in relation to birth weight. BJOG. 1987;94:678–681
  28. Bardy AH, Seppala T, Lillsunde P, Kataja JM, Koskela P, Pikkarainen J, et al. Objectively measured tobacco exposure during pregnancy: neonatal effects and relation to maternal smoking. BJOG. 1993;100:721–726
  29. Doll R. Fifty years of research on tobacco. J Epidemiol Biostat. 2000;5:321–329
  30. Bennett WA, Lagoo-Deenadayalan S, Whitworth NS, Stopple JA, Barber WH, Hale E, et al. First-trimester human chorionic villi express both immunoregulatory and inflammatory cytokines: a role for interleukin-10 in regulating the cytokine network of pregnancy. Am J Reprod Immunol (Copenhagen). 1999;41:70–78

 Supported by National Institute of Child Health and Human Development grants 1 R01 HD41663-01A1 and MO1-RR000056.Presented in part at the annual meeting of the Infectious Diseases Society for Obstetrics and Gynecology, San Diego, CA, August 5-7, 2004.Reprints not available from the authors.

PII: S0002-9378(05)00641-1

doi: 10.1016/j.ajog.2005.04.054

American Journal of Obstetrics & Gynecology
Volume 193, Issue 6 , Pages 1999-2003 , December 2005

Article Tools

* Image Usage & Resolution