« Previous
Next »
American Journal of Obstetrics & Gynecology
Volume 192, Issue 4
, Pages 1256-1260
, April 2005
Telomere length predicts embryo fragmentation after in vitro fertilization in women—Toward a telomere theory of reproductive aging in women
References
- . Telomere states and cell fates. Nature. 2000;408:53–56
- . The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965;37:614–636
- Extension of life-span by introduction of telomerase into normal human cells. Science. 1998;279:349–352
- . Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol. 1998;8:279–282
- . Telomerase activity in human germline and embryonic tissues and cells. Dev Genet. 1996;18:173–179
- Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997;91:25–34
- . Telomere shortening in mTR−/− embryos is associated with failure to close the neural tube. EMBO J. 1999;18:1172–1181
- . Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 1999;18:2950–2960
- . Essential role of mouse telomerase in highly proliferative organs. Nature. 1998;392:569–574
- . Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 1999;96:701–712
- . An essential role for functional telomeres in mouse germ cells during fertilization and early development. Dev Biol. 2002;249:74–84
- . Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles. EMBO Reports. 2002;3:230–234
- . Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell. 2002;1:40–46
- . Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability and apoptosis. J Biol Chem. 2003;278:1998–2004
- . Irregular telomeres impair meiotic synapsis and recombination in mice. Proc Natl Acad Sci U S A. 2004;101:6496–6501
- . Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and caspase-3 in blastomere fragmentation. Molec Hum Repro. 2003;9:133–142
- . Selection based on morphological assessment of oocytes and embryos at different stages of preimplantation development: a review. Hum Reprod Update. 2003;9:251–262
- . The transfer point is a novel measure of embryo placement. Fertil Steril. 2003;79:1416–1421
- Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci U S A. 1997;94:7423–7428
- . Telomere length measurements using digital fluorescence microscopy. Cytometry. 1999;36:267–278
- Telomere abnormalities in mammalian radiosensitive cells. Cancer Res. 2001;61:912–915
- . Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell. 2002;1:40–46
- . P53 Good cop/bad cop. Cell. 2002;110:9–12
- . Haploidy but not parthenogenetic activation leads to increased incidence of apoptosis in mouse embryos. Biol Reprod. 2002;66:204–210
- . A test of the production line hypothesis of mammalian oogenesis. Hum Genet. 1991;88:64–70
- . Oral antioxidants counteract the negative effects of female aging on oocyte quantity and quality in the mouse. Molec Reprod Develop. 2002;61:385–397
- . Mitochondrial DNA deletions in oocytes and reproductive aging in women. Fertil Steril. 1995;64:577–583
- . To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2003;2:280–291
- . Embryo morphology, development rates and maternal age are correlated with chromosome abnormalities. Fertil Steril. 1995;64:382–391
Supported by grants from the Women and Infants Hospital/Brown Faculty Research Fund to D.K., and by the Ministry of Science and Technology (PM97-0133), Spain, and from the European Union (EURATOM/991/0201, FIGH-CT-1999-00002, FIS5-1999-00055) to M.A.B.Presented at the 23rd Annual Meeting of the American Gynecological and Obstetrical Society, September 9-11, 2004, Bolton Landing, NY.
PII: S0002-9378(05)00113-4
doi: 10.1016/j.ajog.2005.01.036
© 2005 Elsevier Inc. All rights reserved.
« Previous
Next »
American Journal of Obstetrics & Gynecology
Volume 192, Issue 4
, Pages 1256-1260
, April 2005
