American Journal of Obstetrics & Gynecology
Volume 172, Issue 2, Part 1 , Pages 695-699 , February 1995

Serum CA 125 levels and spontaneous abortion

  • Mark D. Hornstein, MD

      Affiliations

    • Corresponding Author InformationReprint requests: Mark D. Hornstein, MD, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115.
    • Departments of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    • ,
  • Jerome H. Check, MD

      Affiliations

    • University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School of Camden, Cooper University Hospital Camden, New Jersey, USA
    • ,
  • Joseph A. Hill, MD

      Affiliations

    • Departments of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA

Received 10 January 1994 ,Revised 20 April 1994 ,Accepted 27 June 1994.

References 

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  2. Kabawat SE, Bast RC, Bhan AK, Welch WR, Knapp RC, Colvin RB. Tissue distribution of a coelomic-epithelium related antigen recognized by the monoclonal antibody OC-125. Int J Gynecol Pathol. 1983;2:275–285
  3. Masuho Y, Zalutsky M, Knapp RC, Bast RC. Interaction of monoclonal antibodies with cell surface antigens of human ovarian carcinoma. Cancer Res. 1984;44:2813–2819
  4. Niloff JM, Knapp RC, Schnaetzl E, Reynolds C, Bast RC. CA-125 antigen levels in obstetric and gynecologic patients. Obstet Gynecol. 1984;64:703–707
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  7. Kobabyashi F, Sagawa N, Nakamura K, et al.  Mechanism and clinical significanbce of elevated CA-125 levels in the sera of pregnant women. Am J Obstet Gynecol. 1989;160:563–566
  8. Check JM, Nowroozi K, Winkel CA, Johnson T, Seefried L. Serum CA-125 levels in early pregnancy and subsequent spontaneous abortion. Obstet Gynecol. 1990;75:742–744
  9. Check JM, Nowroozi K, Vaze M, Wapner R, Seefried L. Very high CA 125 levels during early first trimester in three cases of spontaneous abortion with chromosomal abnormalities. Am J Obstet Gynecol. 1990;162:674–675
  10. Brumstead JR, Nakajima ST, Badger G, Riddick DH, Gibson M. Serum concentration of CA-125 during the first trimester of normal and abnormal pregnancies. J Reprod Med. 1990;35:499–503
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  12. Witt BR, Wolf GC, Wainwright CJ, Johnston PD, Thorneycroft IH. Relaxin, CA-125, progesterone, estradiol, Schwangerschaft protein, and human chorionic gonadotropin as predictors of outcome in threatened and non-threatened pregnancies. Fertil Steril. 1990;53:1029–1036
  13. Barbati A, Anceschi MM, Alberti P, Pomili G, Di Renzo GC, Cosmi EV. Ontogeny of CA-125 antigen in pregnancy: immunoradiometric determination in amniotic fluid and immunohistochemical localization in fetal membranes. Am J Obstet Gynecol. 1989;160:514–517
  14. Quirk JG, Brunson GL, Long CA, Bannon GA, Sanders MM, O'Brien TJ. CA 125 in tissues and amniotic fluid during pregnancy. Am J Obstet Gynecol. 1988;159:644–649
  15. Jacobs IJ, Fay TN, STabile I, Bridges JE, Oram DH, Grudzinskas JG. The distribution of CA-125 in the reproductive tract of pregnant and nonpregnant women. Br J Obstet Gynecol. 1988;95:1190–1194
  16. Fuith LL, Muller-Holzner E, Marth C, Perkmann E, Zeimet A, Daxenbichler G. Distribution of CA-125 in placental tissues. Int J Biol Markers. 1989;4:78–80
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  18. Kobayashi F, Sagawa N, Nanbu Y, et al.  Immunohistochemical localization and tissue levels of tumor-associated glycoproteins CA 125 and CA-19-9 in the decidua and fetal membranes at various gestational ages. Am J Obstet Gynecol. 1989;160:232–1238
  19. Spencer K. Maternal serum CA-125 is not a second trimester marker for Down's syndrome. Am Clin Biochem. 1991;28:299–300

☆ Supported in part by a grant from Centocor, Inc. and by National Institutes of Health grant No. MO1 RR02635 to the Brigham and Women's Hospital General Clinical Research Center.

PII: 0002-9378(95)90596-0

American Journal of Obstetrics & Gynecology
Volume 172, Issue 2, Part 1 , Pages 695-699 , February 1995

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